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10.3389/fmed.2015.00069 http://scihub22266oqcxt.onion/10.3389/fmed.2015.00069 C4585048!4585048 !26442271     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26442271 &cmd=llinks): Failed to open stream: HTTP request failed! 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Interleukin(IL)-36? and IL-36? Induce Proinflammatory Mediators from Human Colonic Subepithelial Myofibroblasts |pdf=|usr=}}{{26442271 }} gab.com Text Interleukin(IL)-36 and IL-36 Induce Proinflammatory Mediators from Human Colonic Subepithelial Myofibroblasts JO: Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=26442271 #FOAvip BACKGROUND: Interleukin (IL)-36 cytokines are recently reported member of the IL-1 cytokine family. However, there is little information regarding the association between IL-36 cytokines and gut inflammation. In the present study, we investigated the biological activity of IL-36? and IL-36? using human colonic subepithelial myofibroblasts (SEMFs). METHODS: The mRNA expression and the protein expression of target molecules in SEMFs were evaluated using real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The intracellular signaling of IL-36 cytokines was analyzed using Western blot analysis and small interfering RNAs (siRNAs) specific for MyD88 adaptor proteins (MyD88 and IRAK1) and NF-?B p65. RESULTS: IL-36? and IL-36? significantly enhanced the secretion of IL-6 and CXC chemokines (CXCL1, CXCL2, and CXCL8) by SEMFs. The combination of IL-36?/? and IL-17A or of IL-36?/? and tumor necrosis factor-? showed a synergistic effect on the induction of IL-6 and CXC chemokines. The mRNA expression of proinflammatory mediators induced by IL-36? and/or IL-36? was significantly suppressed by transfection of siRNA for MyD88 or IRAK1. Both inhibitors of mitogen activated protein kinases and siRNAs specific for NF-?Bp65 significantly reduced the expression of IL-6 and CXC chemokines induced by IL-36? and/or IL-36?. CONCLUSION: These results suggest that IL-36? and IL-36? contribute to gut inflammation through the induction of proinflammatory mediators. Twit Text FOAVip Interleukin(IL)-36 and IL-36 Induce Proinflammatory Mediators from Human Colonic Subepithelial Myofibroblasts ????Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=26442271 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26442271 #FOAvip English Wikipedia <ref>{{Cite pmid|26442271 }}</ref> Interleukin(IL)-36? and IL-36? Induce Proinflammatory Mediators from Human Colonic Subepithelial Myofibroblasts #MMPMID26442271 Kanda T ; Nishida A ; Takahashi K ; Hidaka K ; Imaeda H ; Inatomi O ; Bamba S ; Sugimoto M ; Andoh A Front Med (Lausanne) 2015[]; 2 (ä): 69 PMID26442271 show ga BACKGROUND: Interleukin (IL)-36 cytokines are recently reported member of the IL-1 cytokine family. However, there is little information regarding the association between IL-36 cytokines and gut inflammation. In the present study, we investigated the biological activity of IL-36? and IL-36? using human colonic subepithelial myofibroblasts (SEMFs). METHODS: The mRNA expression and the protein expression of target molecules in SEMFs were evaluated using real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The intracellular signaling of IL-36 cytokines was analyzed using Western blot analysis and small interfering RNAs (siRNAs) specific for MyD88 adaptor proteins (MyD88 and IRAK1) and NF-?B p65. RESULTS: IL-36? and IL-36? significantly enhanced the secretion of IL-6 and CXC chemokines (CXCL1, CXCL2, and CXCL8) by SEMFs. The combination of IL-36?/? and IL-17A or of IL-36?/? and tumor necrosis factor-? showed a synergistic effect on the induction of IL-6 and CXC chemokines. The mRNA expression of proinflammatory mediators induced by IL-36? and/or IL-36? was significantly suppressed by transfection of siRNA for MyD88 or IRAK1. Both inhibitors of mitogen activated protein kinases and siRNAs specific for NF-?Bp65 significantly reduced the expression of IL-6 and CXC chemokines induced by IL-36? and/or IL-36?. CONCLUSION: These results suggest that IL-36? and IL-36? contribute to gut inflammation through the induction of proinflammatory mediators. äInterleukin(IL)-36? and IL-36? Induce Proinflammatory Mediators from H(epmc).pdf DeepDyve Pubget Overpricing