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10.3389/fpls.2015.00757

http://scihub22266oqcxt.onion/10.3389/fpls.2015.00757
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C4584954!4584954!26442070
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suck abstract from ncbi


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pmid26442070      Front+Plant+Sci 2015 ; 6 (ä): ä
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  • Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants #MMPMID26442070
  • Samanta S; Thakur JK
  • Front Plant Sci 2015[]; 6 (ä): ä PMID26442070show ga
  • Basic transcriptional machinery in eukaryotes is assisted by a number of cofactors, which either increase or decrease the rate of transcription. Mediator complex is one such cofactor, and recently has drawn a lot of interest because of its integrative power to converge different signaling pathways before channeling the transcription instructions to the RNA polymerase II machinery. Like yeast and metazoans, plants do possess the Mediator complex across the kingdom, and its isolation and subunit analyses have been reported from the model plant, Arabidopsis. Genetic, and molecular analyses have unraveled important regulatory roles of Mediator subunits at every stage of plant life cycle starting from flowering to embryo and organ development, to even size determination. It also contributes immensely to the survival of plants against different environmental vagaries by the timely activation of its resistance mechanisms. Here, we have provided an overview of plant Mediator complex starting from its discovery to regulation of stoichiometry of its subunits. We have also reviewed involvement of different Mediator subunits in different processes and pathways including defense response pathways evoked by diverse biotic cues. Wherever possible, attempts have been made to provide mechanistic insight of Mediator's involvement in these processes.
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