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2015 ; 6
(ä): 757
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Importance of Mediator complex in the regulation and integration of diverse
signaling pathways in plants
#MMPMID26442070
Samanta S
; Thakur JK
Front Plant Sci
2015[]; 6
(ä): 757
PMID26442070
show ga
Basic transcriptional machinery in eukaryotes is assisted by a number of
cofactors, which either increase or decrease the rate of transcription. Mediator
complex is one such cofactor, and recently has drawn a lot of interest because of
its integrative power to converge different signaling pathways before channeling
the transcription instructions to the RNA polymerase II machinery. Like yeast and
metazoans, plants do possess the Mediator complex across the kingdom, and its
isolation and subunit analyses have been reported from the model plant,
Arabidopsis. Genetic, and molecular analyses have unraveled important regulatory
roles of Mediator subunits at every stage of plant life cycle starting from
flowering to embryo and organ development, to even size determination. It also
contributes immensely to the survival of plants against different environmental
vagaries by the timely activation of its resistance mechanisms. Here, we have
provided an overview of plant Mediator complex starting from its discovery to
regulation of stoichiometry of its subunits. We have also reviewed involvement of
different Mediator subunits in different processes and pathways including defense
response pathways evoked by diverse biotic cues. Wherever possible, attempts have
been made to provide mechanistic insight of Mediator's involvement in these
processes.