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10.3390/membranes5030288 http://scihub22266oqcxt.onion/10.3390/membranes5030288 C4584283!4584283!26154780     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Membranes+(Basel) 2015 ; 5 (3): 288-306 Nephropedia Template TP {{tp|p=26154780|t=2015. Retromer-Mediated Trafficking of Transmembrane Receptors and Transporters |pdf=|usr=}}{{26154780}} gab.com Text Retromer-Mediated Trafficking of Transmembrane Receptors and Transporters JO: Membranes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26154780 #FOAvip Transport between the endoplasmatic reticulum, the Golgi-network, the endo-lysosomal system and the cell surface can be categorized as anterograde or retrograde, describing traffic that goes forward or backward, respectively. Traffic going from the plasma membrane to endosomes and lysosomes or the trans-Golgi network (TGN) constitutes the major retrograde transport routes. Several transmembrane proteins undergo retrograde transport as part of a recycling mechanism that contributes to reutilization and maintenance of a steady-state protein localization. In addition, some receptors are hijacked by exotoxins and used for entry and intracellular transport. The physiological relevance of retrograde transport cannot be overstated. Retrograde trafficking of the amyloid precursor protein determines the distribution between organelles, and hence the possibility of cleavage by ?-secretase. Right balancing of the pathways is critical for protection against Alzheimer?s disease. During embryonic development, retrograde transport of Wntless to the TGN is essential for the following release of Wnt from the plasma membrane. Furthermore, overexpression of Wntless has been linked to oncogenesis. Here, we review relevant aspects of the retrograde trafficking of mammalian transmembrane receptors and transporters, with focus on the retromer-mediated transport between endosomes and the TGN. Twit Text FOAVip Retromer-Mediated Trafficking of Transmembrane Receptors and Transporters ????Membranes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26154780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26154780 #FOAvip English Wikipedia <ref>{{Cite pmid|26154780}}</ref> Retromer-Mediated Trafficking of Transmembrane Receptors and Transporters #MMPMID26154780 Klinger SC; Siupka P; Nielsen MS Membranes (Basel) 2015[Sep]; 5 (3): 288-306 PMID26154780show ga Transport between the endoplasmatic reticulum, the Golgi-network, the endo-lysosomal system and the cell surface can be categorized as anterograde or retrograde, describing traffic that goes forward or backward, respectively. Traffic going from the plasma membrane to endosomes and lysosomes or the trans-Golgi network (TGN) constitutes the major retrograde transport routes. Several transmembrane proteins undergo retrograde transport as part of a recycling mechanism that contributes to reutilization and maintenance of a steady-state protein localization. In addition, some receptors are hijacked by exotoxins and used for entry and intracellular transport. The physiological relevance of retrograde transport cannot be overstated. Retrograde trafficking of the amyloid precursor protein determines the distribution between organelles, and hence the possibility of cleavage by ?-secretase. Right balancing of the pathways is critical for protection against Alzheimer?s disease. During embryonic development, retrograde transport of Wntless to the TGN is essential for the following release of Wnt from the plasma membrane. Furthermore, overexpression of Wntless has been linked to oncogenesis. Here, we review relevant aspects of the retrograde trafficking of mammalian transmembrane receptors and transporters, with focus on the retromer-mediated transport between endosomes and the TGN. äRetromer-Mediated Trafficking of Transmembrane Receptors and Transport(epmc).pdf DeepDyve Pubget Overpricing