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10.1155/2015/684965 http://scihub22266oqcxt.onion/10.1155/2015/684965 C4584061!4584061 !26448817     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26448817 &cmd=llinks): Failed to open stream: HTTP request failed! 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Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease |pdf=|usr=}}{{26448817 }} gab.com Text Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease JO: Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=26448817 #FOAvip Our evidence demonstrated that CKD upregulated the expression of myostatin, TNF-?, and p-IkBa and downregulated the phosphorylation of PI3K, Akt, and FoxO3a, which were also associated with protein degradation and muscle atrophy. The autophagosome formation and protein expression of autophagy-related genes were increased in muscle of CKD rats. The mRNA level and protein expression of MAFbx and MuRF-1 were also upregulated in CKD rats, as well as proteasome activity of 26S. Moreover, activation of myostatin elicited by TNF-? induces C2C12 myotube atrophy via upregulating the expression of autophagy-related genes, including MAFbx and MuRF1 and proteasome subunits. Inactivation of FoxO3a triggered by PI3K inhibitor LY294002 prevented the myostatin-induced increase of expression of MuRF1, MAFbx, and LC3-II protein in C2C12 myotubes. The findings were further consolidated by using siRNA interference and overexpression of myostatin. Additionally, expression of myostatin was activated by TNF-? via a NF-?B dependent pathway in C2C12 myotubes, while inhibition of NF-?B activity suppressed myostatin and improved myotube atrophy. Collectively, myostatin mediated CKD-induced muscle catabolism via coordinate activation of the autophagy and the ubiquitin-proteasome systems. Twit Text FOAVip Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease ????Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=26448817 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26448817 #FOAvip English Wikipedia <ref>{{Cite pmid|26448817 }}</ref> Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease #MMPMID26448817 Wang DT ; Yang YJ ; Huang RH ; Zhang ZH ; Lin X Oxid Med Cell Longev 2015[]; 2015 (ä): 684965 PMID26448817 show ga Our evidence demonstrated that CKD upregulated the expression of myostatin, TNF-?, and p-IkBa and downregulated the phosphorylation of PI3K, Akt, and FoxO3a, which were also associated with protein degradation and muscle atrophy. The autophagosome formation and protein expression of autophagy-related genes were increased in muscle of CKD rats. The mRNA level and protein expression of MAFbx and MuRF-1 were also upregulated in CKD rats, as well as proteasome activity of 26S. Moreover, activation of myostatin elicited by TNF-? induces C2C12 myotube atrophy via upregulating the expression of autophagy-related genes, including MAFbx and MuRF1 and proteasome subunits. Inactivation of FoxO3a triggered by PI3K inhibitor LY294002 prevented the myostatin-induced increase of expression of MuRF1, MAFbx, and LC3-II protein in C2C12 myotubes. The findings were further consolidated by using siRNA interference and overexpression of myostatin. Additionally, expression of myostatin was activated by TNF-? via a NF-?B dependent pathway in C2C12 myotubes, while inhibition of NF-?B activity suppressed myostatin and improved myotube atrophy. Collectively, myostatin mediated CKD-induced muscle catabolism via coordinate activation of the autophagy and the ubiquitin-proteasome systems. |Animals [MESH] |Autophagy/genetics [MESH] |Lysosomes/*metabolism [MESH] |Male [MESH] |Muscular Atrophy/*chemically induced/pathology [MESH] |Myostatin/*adverse effects/pharmacology [MESH] |Proteasome Endopeptidase Complex/*metabolism [MESH] |Rats [MESH] |Renal Insufficiency, Chronic [MESH] |Signal Transduction [MESH]Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Sy(epmc).pdf DeepDyve Pubget Overpricing