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2015 ; 2015
(ä): 842975
Nephropedia Template TP
gab.com Text
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English Wikipedia
Comprehensive Review of Adipose Stem Cells and Their Implication in Distraction
Osteogenesis and Bone Regeneration
#MMPMID26448947
Morcos MW
; Al-Jallad H
; Hamdy R
Biomed Res Int
2015[]; 2015
(ä): 842975
PMID26448947
show ga
Bone is one of the most dynamic tissues in the human body that can heal following
injury without leaving a scar. However, in instances of extensive bone loss, this
intrinsic capacity of bone to heal may not be sufficient and external
intervention becomes necessary. Several techniques are available to address this
problem, including autogenous bone grafts and allografts. However, all these
techniques have their own limitations. An alternative method is the technique of
distraction osteogenesis, where gradual and controlled distraction of two bony
segments after osteotomy leads to induction of new bone formation. Although
distraction osteogenesis usually gives satisfactory results, its major limitation
is the prolonged duration of time required before the external fixator is
removed, which may lead to numerous complications. Numerous methods to accelerate
bone formation in the context of distraction osteogenesis have been reported. A
viable alternative to autogenous bone grafts for a source of osteogenic cells is
mesenchymal stem cells from bone marrow. However, there are certain problems with
bone marrow aspirate. Hence, scientists have investigated other sources for
mesenchymal stem cells, specifically adipose tissue, which has been shown to be
an excellent source of mesenchymal stem cells. In this paper, the potential use
of adipose stem cells to stimulate bone formation is discussed.