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10.1155/2015/215135 http://scihub22266oqcxt.onion/10.1155/2015/215135 C4584033!4584033!26448930     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26448930|t=2015. Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment |pdf=|usr=}}{{26448930}} gab.com Text Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26448930 #FOAvip High-grade gliomas are the main cause of death in children with brain tumours. Despite recent advances in cancer therapy, their prognosis remains poor and the treatment is still challenging. To date, surgery followed by radiotherapy and temozolomide is the standard therapy. However, increasing knowledge of glioma biology is starting to impact drug development towards targeted therapies. The identification of agents directed against molecular targets aims at going beyond the traditional therapeutic approach in order to develop a personalized therapy and improve the outcome of pediatric high-grade gliomas. In this paper, we critically review the literature regarding the genetic abnormalities implicated in the pathogenesis of pediatric malignant gliomas and the current development of molecularly targeted therapies. In particular, we analyse the impact of molecular biology on the prognosis and treatment of pediatric high-grade glioma, comparing it to that of adult gliomas. Twit Text FOAVip Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26448930 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26448930 #FOAvip English Wikipedia <ref>{{Cite pmid|26448930}}</ref> Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment #MMPMID26448930 Rizzo D; Ruggiero A; Martini M; Rizzo V; Maurizi P; Riccardi R Biomed Res Int 2015[]; 2015 (ä): ä PMID26448930show ga High-grade gliomas are the main cause of death in children with brain tumours. Despite recent advances in cancer therapy, their prognosis remains poor and the treatment is still challenging. To date, surgery followed by radiotherapy and temozolomide is the standard therapy. However, increasing knowledge of glioma biology is starting to impact drug development towards targeted therapies. The identification of agents directed against molecular targets aims at going beyond the traditional therapeutic approach in order to develop a personalized therapy and improve the outcome of pediatric high-grade gliomas. In this paper, we critically review the literature regarding the genetic abnormalities implicated in the pathogenesis of pediatric malignant gliomas and the current development of molecularly targeted therapies. In particular, we analyse the impact of molecular biology on the prognosis and treatment of pediatric high-grade glioma, comparing it to that of adult gliomas. äMolecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis (epmc).pdf DeepDyve Pubget Overpricing