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2015 ; 8
(8
): 9390-6
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Possibility of D2-40 as a diagnostic and tumor differentiation-suggestive marker
for some of phosphaturic mesenchymal tumors
#MMPMID26464693
Tajima S
; Fukayama M
Int J Clin Exp Pathol
2015[]; 8
(8
): 9390-6
PMID26464693
show ga
Phosphaturic mesenchymal tumor (PMT) has been established as a tumor that causes
tumor-induced osteomalacia (TIO) associated with mesenchymal neoplasm. Its
lineage of differentiation has not been elucidated. Previously, the presence of
lymphatic vessels inside PMTs has been documented using an anti-podoplanin
antibody; the tumor cells of PMTs were reported to not react with it. In this
study of 14 cases of PMTs, we used immunohistochemistry of D2-40, a relatively
specific lymphatic endothelial marker, to see if they stained PMTs or not, with
particular interest in its reaction with microcystic structures containing
lymph-like fluid. We report that most of the PMTs (12 out of 14 cases; 86%) were
immunostained by D2-40 in their tumor cells; D2-40-positive lymphatic vessels
inside the tumor were also observed. We used a proportion score (0-4+), an
intensity score (0-3+), and a total score (the sum of the proportion score and
the intensity score) to quantitate our results. We report that 50% of cases (7
out of 14 cases) had a total score ? 4+; immunostaining of D2-40 in cases with a
total score ? 4+ was easy to observe at a glance. Most of the tumor cells lining
the microcystic structures were immunostained with D2-40. Thus, D2-40 could be a
useful diagnostic marker of PMTs and it might also indicate that PMTs take a
lymphatic endothelial immunophenotype.