Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26464658
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Clin+Exp+Pathol
2015 ; 8
(8
): 9140-6
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Knockdown of long noncoding RNA SPRY4-IT1 suppresses glioma cell proliferation,
metastasis and epithelial-mesenchymal transition
#MMPMID26464658
Liu H
; Lv Z
; Guo E
Int J Clin Exp Pathol
2015[]; 8
(8
): 9140-6
PMID26464658
show ga
Long noncoding RNAs (lncRNAs), a class of ribonucleic molecules, participate in
various cellular processes. They are highly expressed in several types of cancer
and their expression was related to pathophysiological characteristics of tumor
growth, therefore, they can be considered as a promising diagnostic tool and a
convenient prognostic biomarker. SPRY4-IT1, belonging to a group of
intron-retained lncRNAs, was reported to affect tumor development of many types
of cancer. However, the expression and the role of SPRY4-IT1 in glioma are still
unclear. Therefore, in this study, we examined for the first time the expression
and role of SPRY4-IT1 in glioma cells. The results of our study showed that
SPRY4-IT1 was up-regulated in human glioma tissues and cell lines. Knockdown of
SPRY4-IT1 could inhibit glioma cell growth and migration. Moreover, knockdown of
SPRY4-IT1 could inhibit epithelial-mesenchymal transition (EMT) phenotype in
glioma cells. Based on these findings, SPRY4-IT1 may be used as a new target for
diagnosis and treatment of glioma.