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10.1016/j.biomaterials.2015.06.004 http://scihub22266oqcxt.onion/10.1016/j.biomaterials.2015.06.004 C4583713!4583713!26081866     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomaterials 2015 ; 63 (ä): 35-46 Nephropedia Template TP {{tp|p=26081866|t=2015. Lhx8 Mediated Wnt and TGF? Pathways in Tooth Development and Regeneration |pdf=|usr=}}{{26081866}} gab.com Text Lhx8 Mediated Wnt and TGF Pathways in Tooth Development and Regeneration JO: Biomaterials http://www.kidney.de/pget.php?&tw=1&pmid=26081866 #FOAvip LIM homeobox 8 (Lhx8) is a highly conserved transcriptional factor with recently illustrated roles in cholinergic and GABAergic differentiation, and is expressed in neural crest derived craniofacial tissues during development. However, Lhx8 functions and signaling pathways are largely elusive. Here we showed that Lhx8 regulates dental mesenchyme differentiation and function via Wnt and TGF? pathways. Lhx8 expression was restricted to dental mesenchyme from E11.5 to a peak at E14.5, and absent in dental epithelium. By reconstituting dental epithelium and mesenchyme in an E16.5 tooth organ, Lhx8 knockdown accelerated dental mesenchyme differentiation; conversely, Lhx8 overexpression attenuated dentin formation. Lhx8 overexpressed adult human dental pulp stem/progenitor cells in ?-tricalcium phosphate cubes attenuated mineralized matrix production in vivo. Gene profiling revealed that postnatal dental pulp stem/progenitor cells upon Lhx8 overexpression modified several matrix related gene expression including Dspp, Cola1 and osteocalcin. Lhx8 transcriptionally activates Wnt and TGF? pathways, and its attenuation upregulates multiple dentinogenesis genes. Together, Lhx8 regulates dentin development and regeneration by fine-turning Wnt and TGF? signaling. Twit Text FOAVip Lhx8 Mediated Wnt and TGF Pathways in Tooth Development and Regeneration ????Biomaterials http://www.kidney.de/pget.php?&tw=1&pmid=26081866 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26081866 #FOAvip English Wikipedia <ref>{{Cite pmid|26081866}}</ref> Lhx8 Mediated Wnt and TGF? Pathways in Tooth Development and Regeneration #MMPMID26081866 Zhou C; Yang G; Chen M; Wang C; He L; Xiang L; Chen D; Ling J; Mao JJ Biomaterials 2015[Sep]; 63 (ä): 35-46 PMID26081866show ga LIM homeobox 8 (Lhx8) is a highly conserved transcriptional factor with recently illustrated roles in cholinergic and GABAergic differentiation, and is expressed in neural crest derived craniofacial tissues during development. However, Lhx8 functions and signaling pathways are largely elusive. Here we showed that Lhx8 regulates dental mesenchyme differentiation and function via Wnt and TGF? pathways. Lhx8 expression was restricted to dental mesenchyme from E11.5 to a peak at E14.5, and absent in dental epithelium. By reconstituting dental epithelium and mesenchyme in an E16.5 tooth organ, Lhx8 knockdown accelerated dental mesenchyme differentiation; conversely, Lhx8 overexpression attenuated dentin formation. Lhx8 overexpressed adult human dental pulp stem/progenitor cells in ?-tricalcium phosphate cubes attenuated mineralized matrix production in vivo. Gene profiling revealed that postnatal dental pulp stem/progenitor cells upon Lhx8 overexpression modified several matrix related gene expression including Dspp, Cola1 and osteocalcin. Lhx8 transcriptionally activates Wnt and TGF? pathways, and its attenuation upregulates multiple dentinogenesis genes. Together, Lhx8 regulates dentin development and regeneration by fine-turning Wnt and TGF? signaling. äLhx8 Mediated Wnt and TGF? Pathways in Tooth Development and Regenerat(epmc).pdf DeepDyve Pubget Overpricing