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10.1016/j.neuron.2015.08.030 http://scihub22266oqcxt.onion/10.1016/j.neuron.2015.08.030 C4583656!4583656 !26402608     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26402608 &cmd=llinks): Failed to open stream: HTTP request failed! 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Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps |pdf=|usr=}}{{26402608 }} gab.com Text Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=26402608 #FOAvip Topographic maps in visual processing areas maintain the spatial order of the visual world. Molecular cues and neuronal activity both play critical roles in map formation, but their interaction remains unclear. Here, we demonstrate that when molecular- and activity-dependent cues are rendered nearly equal in force, they drive topographic mapping stochastically. The functional and anatomical representation of azimuth in the superior colliculus of heterozygous Islet2-EphA3 knockin (Isl2(EphA3/+)) mice is variable: maps may be single, duplicated, or a combination of the two. This heterogeneity is not due to genetic differences, since map organizations in individual mutant animals often differ between colliculi. Disruption of spontaneous waves of retinal activity resulted in uniform map organization in Isl2(EphA3/+) mice, demonstrating that correlated spontaneous activity is required for map heterogeneity. Computational modeling replicates this heterogeneity, revealing that molecular- and activity-dependent forces interact simultaneously and stochastically during topographic map formation. Twit Text FOAVip Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=26402608 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26402608 #FOAvip English Wikipedia <ref>{{Cite pmid|26402608 }}</ref> Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps #MMPMID26402608 Owens MT ; Feldheim DA ; Stryker MP ; Triplett JW Neuron 2015[Sep]; 87 (6 ): 1261-1273 PMID26402608 show ga Topographic maps in visual processing areas maintain the spatial order of the visual world. Molecular cues and neuronal activity both play critical roles in map formation, but their interaction remains unclear. Here, we demonstrate that when molecular- and activity-dependent cues are rendered nearly equal in force, they drive topographic mapping stochastically. The functional and anatomical representation of azimuth in the superior colliculus of heterozygous Islet2-EphA3 knockin (Isl2(EphA3/+)) mice is variable: maps may be single, duplicated, or a combination of the two. This heterogeneity is not due to genetic differences, since map organizations in individual mutant animals often differ between colliculi. Disruption of spontaneous waves of retinal activity resulted in uniform map organization in Isl2(EphA3/+) mice, demonstrating that correlated spontaneous activity is required for map heterogeneity. Computational modeling replicates this heterogeneity, revealing that molecular- and activity-dependent forces interact simultaneously and stochastically during topographic map formation. |*Cues [MESH] |Animals [MESH] |Brain Mapping/*methods [MESH] |Gene Knock-In Techniques [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Neurons/*physiology [MESH] |Retinal Ganglion Cells/*physiology [MESH] |Stochastic Processes [MESH] |Superior Colliculi/cytology/*physiology [MESH]Stochastic Interaction between Neural Activity and Molecular Cues in t(epmc).pdf DeepDyve Pubget Overpricing