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10.1371/journal.pone.0136779 http://scihub22266oqcxt.onion/10.1371/journal.pone.0136779 C4583308!4583308 !26406980     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26406980 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (9 ): e0136779 Nephropedia Template TP {{tp|p=26406980 |t=2015. The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters |pdf=|usr=}}{{26406980 }} gab.com Text The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26406980 #FOAvip Equilibrative nucleoside transporters (ENTs) are integral membrane proteins, which reside in plasma membranes of all eukaryotic cells and mediate thermodynamically downhill transport of nucleosides. This process is essential for nucleoside recycling, and also plays a key role in terminating adenosine-mediated cellular signaling. Furthermore, ENTs mediate the uptake of many drugs, including anticancer and antiviral nucleoside analogues. The structure and mechanism, by which ENTs catalyze trans-membrane transport of their substrates, remain unknown. To identify the core of the transporter needed for stability, activity, and for its correct trafficking to the plasma membrane, we have expressed human ENT deletion mutants in Xenopus laevis oocytes and determined their localization, transport properties and susceptibility to inhibition. We found that the carboxyl terminal trans-membrane segments are essential for correct protein folding and trafficking. In contrast, the soluble extracellular and intracellular loops appear to be dispensable, and must be involved in the fine-tuning of transport regulation. Twit Text FOAVip The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26406980 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26406980 #FOAvip English Wikipedia <ref>{{Cite pmid|26406980 }}</ref> The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters #MMPMID26406980 Aseervatham J ; Tran L ; Machaca K ; Boudker O PLoS One 2015[]; 10 (9 ): e0136779 PMID26406980 show ga Equilibrative nucleoside transporters (ENTs) are integral membrane proteins, which reside in plasma membranes of all eukaryotic cells and mediate thermodynamically downhill transport of nucleosides. This process is essential for nucleoside recycling, and also plays a key role in terminating adenosine-mediated cellular signaling. Furthermore, ENTs mediate the uptake of many drugs, including anticancer and antiviral nucleoside analogues. The structure and mechanism, by which ENTs catalyze trans-membrane transport of their substrates, remain unknown. To identify the core of the transporter needed for stability, activity, and for its correct trafficking to the plasma membrane, we have expressed human ENT deletion mutants in Xenopus laevis oocytes and determined their localization, transport properties and susceptibility to inhibition. We found that the carboxyl terminal trans-membrane segments are essential for correct protein folding and trafficking. In contrast, the soluble extracellular and intracellular loops appear to be dispensable, and must be involved in the fine-tuning of transport regulation. |*Amino Acid Sequence [MESH] |*Protein Folding [MESH] |*Sequence Deletion [MESH] |Animals [MESH] |Cell Membrane/genetics/*metabolism [MESH] |Equilibrative Nucleoside Transporter 1/genetics/*metabolism [MESH] |Humans [MESH] |Protein Structure, Secondary [MESH] |Protein Transport/physiology [MESH]The Role of Flexible Loops in Folding, Trafficking and Activity of Equ(epmc).pdf DeepDyve Pubget Overpricing