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10.1371/journal.pone.0138792 http://scihub22266oqcxt.onion/10.1371/journal.pone.0138792 C4583221!4583221!26405814     free     free     free       PLoS+One 2015 ; 10 (9): ä Nephropedia Template TP {{tp|p=26405814|t=2015. Involvement of SARA in Axon and Dendrite Growth |pdf=|usr=}}{{26405814}} gab.com Text Involvement of SARA in Axon and Dendrite Growth JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26405814 #FOAvip SARA (Smad Anchor for Receptor Activation) plays a crucial role in Rab5-mediated endocytosis in cell lines localizing to early endosomes where it regulates morphology and function. Here, we analyzed the role of SARA during neuronal development and tested whether it functions as a regulator of endocytic trafficking of selected axonal and membrane proteins. Suppression of SARA perturbs the appearance of juxtanuclear endocytic recycling compartments and the neurons show long axons with large growth cones. Furthermore, surface distribution of the cell adhesion molecule L1 in axons and the fusion of vesicles containing transferring receptor (TfR) in dendrites were increased in neurons where SARA was silenced. Conversely, SARA overexpression generated large early endosomes and reduced neurite outgrowth. Taken together, our findings suggest a significant contribution of SARA to key aspects of neuronal development, including neurite formation. Twit Text FOAVip Involvement of SARA in Axon and Dendrite Growth ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26405814 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26405814 #FOAvip English Wikipedia <ref>{{Cite pmid|26405814}}</ref> Involvement of SARA in Axon and Dendrite Growth #MMPMID26405814 Arias CI; Siri SO; Conde C PLoS One 2015[]; 10 (9): ä PMID26405814show ga SARA (Smad Anchor for Receptor Activation) plays a crucial role in Rab5-mediated endocytosis in cell lines localizing to early endosomes where it regulates morphology and function. Here, we analyzed the role of SARA during neuronal development and tested whether it functions as a regulator of endocytic trafficking of selected axonal and membrane proteins. Suppression of SARA perturbs the appearance of juxtanuclear endocytic recycling compartments and the neurons show long axons with large growth cones. Furthermore, surface distribution of the cell adhesion molecule L1 in axons and the fusion of vesicles containing transferring receptor (TfR) in dendrites were increased in neurons where SARA was silenced. Conversely, SARA overexpression generated large early endosomes and reduced neurite outgrowth. Taken together, our findings suggest a significant contribution of SARA to key aspects of neuronal development, including neurite formation. äInvolvement of SARA in Axon and Dendrite Growth (epmc).pdf DeepDyve Pubget Overpricing