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10.1177/0194599812440419 http://scihub22266oqcxt.onion/10.1177/0194599812440419 C4583202!4583202 !22399283     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22399283 &cmd=llinks): Failed to open stream: HTTP request failed! 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Modulation of inflammatory and profibrotic signaling in a rabbit model of acute phonotrauma using triamcinolone |pdf=|usr=}}{{22399283 }} gab.com Text Modulation of inflammatory and profibrotic signaling in a rabbit model of acute phonotrauma using triamcinolone JO: Otolaryngol Head Neck Surg http://www.kidney.de/pget.php?&tw=1&pmid=22399283 #FOAvip OBJECTIVE: To investigate the hypothesis that prophylactic triamcinolone modulates acute vocal fold inflammatory and profibrotic signaling during acute phonotrauma. STUDY DESIGN: In vivo rabbit phonation model. SETTING: Academic medical center. SUBJECTS AND METHODS: Forty New Zealand white breeder rabbits were randomly assigned to 1 of 4 groups: control (no intervention), no treatment (30 minutes of raised intensity phonation), sham treatment (bilateral intralaryngeal triamcinolone acetonide injection at 0 µg/25 µL followed by 30 minutes of raised intensity phonation), or steroid treatment (bilateral intralaryngeal triamcinolone acetonide injection at 400 µg/25 µL followed by 30 minutes of raised intensity phonation). Quantitative polymerase chain reaction (qPCR) was used to investigate gene expression levels of cyclooxygenase-2 (COX-2), interleukin (IL)-1?, and transforming growth factor (TGF)-?1. RESULTS: Results revealed a significant main effect for COX-2 (P = .002). Post hoc testing revealed that rabbits receiving no treatment (15.10) had higher COX-2 gene expression than control (5.90; P < .001). There were no significant differences in COX-2 expression between treatment groups. Results revealed a significant main effect for IL-1? (P < .001). Post hoc testing revealed that rabbits receiving no treatment (14.70) had higher IL-1? gene expression than control (6.30) (P = .001). There were no significant differences in IL-1? gene expression between treatment groups. There were no significant differences in TGF-?1 gene expression (P = .525) between treatment and control groups. CONCLUSION: Given conflicting evidence, further studies are necessary to investigate vocal fold steroid injections prior to and following the induction of phonotrauma. Prophylactic administration of triamcinolone immediately prior to acute phonotrauma resulted in no significant changes in COX-2, IL-1?, and TGF-?1 gene transcript levels. Twit Text FOAVip Modulation of inflammatory and profibrotic signaling in a rabbit model of acute phonotrauma using triamcinolone ????Otolaryngol Head Neck Surg http://www.kidney.de/pget.php?&tw=1&pmid=22399283 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22399283 #FOAvip English Wikipedia <ref>{{Cite pmid|22399283 }}</ref> Modulation of inflammatory and profibrotic signaling in a rabbit model of acute phonotrauma using triamcinolone #MMPMID22399283 Hall JE ; Suehiro A ; Branski RC ; Garrett CG ; Rousseau B Otolaryngol Head Neck Surg 2012[Aug]; 147 (2 ): 302-7 PMID22399283 show ga OBJECTIVE: To investigate the hypothesis that prophylactic triamcinolone modulates acute vocal fold inflammatory and profibrotic signaling during acute phonotrauma. STUDY DESIGN: In vivo rabbit phonation model. SETTING: Academic medical center. SUBJECTS AND METHODS: Forty New Zealand white breeder rabbits were randomly assigned to 1 of 4 groups: control (no intervention), no treatment (30 minutes of raised intensity phonation), sham treatment (bilateral intralaryngeal triamcinolone acetonide injection at 0 µg/25 µL followed by 30 minutes of raised intensity phonation), or steroid treatment (bilateral intralaryngeal triamcinolone acetonide injection at 400 µg/25 µL followed by 30 minutes of raised intensity phonation). Quantitative polymerase chain reaction (qPCR) was used to investigate gene expression levels of cyclooxygenase-2 (COX-2), interleukin (IL)-1?, and transforming growth factor (TGF)-?1. RESULTS: Results revealed a significant main effect for COX-2 (P = .002). Post hoc testing revealed that rabbits receiving no treatment (15.10) had higher COX-2 gene expression than control (5.90; P < .001). There were no significant differences in COX-2 expression between treatment groups. Results revealed a significant main effect for IL-1? (P < .001). Post hoc testing revealed that rabbits receiving no treatment (14.70) had higher IL-1? gene expression than control (6.30) (P = .001). There were no significant differences in IL-1? gene expression between treatment groups. There were no significant differences in TGF-?1 gene expression (P = .525) between treatment and control groups. CONCLUSION: Given conflicting evidence, further studies are necessary to investigate vocal fold steroid injections prior to and following the induction of phonotrauma. Prophylactic administration of triamcinolone immediately prior to acute phonotrauma resulted in no significant changes in COX-2, IL-1?, and TGF-?1 gene transcript levels. |Acute Disease [MESH] |Animals [MESH] |Cyclooxygenase 2/drug effects/genetics [MESH] |Disease Models, Animal [MESH] |Fibrosis/genetics/prevention & control [MESH] |Gene Expression/drug effects [MESH] |Glucocorticoids/*therapeutic use [MESH] |Inflammation/genetics/prevention & control [MESH] |Interleukin-1beta/drug effects/*genetics [MESH] |Rabbits [MESH] |Signal Transduction [MESH] |Transforming Growth Factor beta1/drug effects/genetics [MESH] |Triamcinolone/*therapeutic use [MESH] |Vocal Cords/*pathology [MESH]Modulation of inflammatory and profibrotic signaling in a rabbit model(epmc).pdf DeepDyve Pubget Overpricing