Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26412909
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Stat+Comput+Simul
2015 ; 85
(9
): 1902-1916
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Variable selection models based on multiple imputation with an application for
predicting median effective dose and maximum effect
#MMPMID26412909
Wan Y
; Datta S
; Conklin DJ
; Kong M
J Stat Comput Simul
2015[]; 85
(9
): 1902-1916
PMID26412909
show ga
The statistical methods for variable selection and prediction could be
challenging when missing covariates exist. Although multiple imputation (MI) is a
universally accepted technique for solving missing data problem, how to combine
the MI results for variable selection is not quite clear, because different
imputations may result in different selections. The widely applied variable
selection methods include the sparse partial least-squares (SPLS) method and the
penalized least-squares method, e.g. the elastic net (ENet) method. In this
paper, we propose an MI-based weighted elastic net (MI-WENet) method that is
based on stacked MI data and a weighting scheme for each observation in the
stacked data set. In the MI-WENet method, MI accounts for sampling and imputation
uncertainty for missing values, and the weight accounts for the observed
information. Extensive numerical simulations are carried out to compare the
proposed MI-WENet method with the other competing alternatives, such as the SPLS
and ENet. In addition, we applied the MIWENet method to examine the predictor
variables for the endothelial function that can be characterized by median
effective dose (ED50) and maximum effect (Emax) in an ex-vivo
phenylephrine-induced extension and acetylcholine-induced relaxation experiment.