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10.1161/CIRCULATIONAHA.111.034512 http://scihub22266oqcxt.onion/10.1161/CIRCULATIONAHA.111.034512 C4583146!4583146 !22082675     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22082675 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Circulation 2011 ; 124 (23 ): 2533-42 Nephropedia Template TP {{tp|p=22082675 |t=2011. A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension |pdf=|usr=}}{{22082675 }} gab.com Text A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension JO: Circulation http://www.kidney.de/pget.php?&tw=1&pmid=22082675 #FOAvip BACKGROUND: Pulmonary hypertension (PH) is a lethal syndrome associated with the pathogenic remodeling of the pulmonary vasculature and the emergence of apoptosis-resistant cells. Apoptosis repressor with caspase recruitment domain (ARC) is an inhibitor of multiple forms of cell death known to be abundantly expressed in striated muscle. We show for the first time that ARC is expressed in arterial smooth muscle cells of the pulmonary vasculature and is markedly upregulated in several experimental models of PH. In this study, we test the hypothesis that ARC expression is essential for the development of chronic hypoxia-induced PH. METHODS AND RESULTS: Experiments in which cells or mice were rendered ARC-deficient revealed that ARC not only protected pulmonary arterial smooth muscle cells from hypoxia-induced death, but also facilitated growth factor-induced proliferation and hypertrophy and hypoxia-induced downregulation of selective voltage-gated potassium channels, the latter a hallmark of the syndrome in humans. Moreover, ARC-deficient mice exhibited diminished vascular remodeling, increased apoptosis, and decreased proliferation in response to chronic hypoxia, resulting in marked protection from PH in vivo. Patients with PH have significantly increased ARC expression not only in remodeled vessels but also in the lumen-occluding lesions associated with severe disease. CONCLUSIONS: These data show that ARC, previously unlinked to pulmonary hypertension, is a critical determinant of vascular remodeling in this syndrome. Twit Text FOAVip A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension ????Circulation http://www.kidney.de/pget.php?&tw=1&pmid=22082675 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22082675 #FOAvip English Wikipedia <ref>{{Cite pmid|22082675 }}</ref> A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension #MMPMID22082675 Zaiman AL ; Damico R ; Thoms-Chesley A ; Files DC ; Kesari P ; Johnston L ; Swaim M ; Mozammel S ; Myers AC ; Halushka M ; El-Haddad H ; Shimoda LA ; Peng CF ; Hassoun PM ; Champion HC ; Kitsis RN ; Crow MT Circulation 2011[Dec]; 124 (23 ): 2533-42 PMID22082675 show ga BACKGROUND: Pulmonary hypertension (PH) is a lethal syndrome associated with the pathogenic remodeling of the pulmonary vasculature and the emergence of apoptosis-resistant cells. Apoptosis repressor with caspase recruitment domain (ARC) is an inhibitor of multiple forms of cell death known to be abundantly expressed in striated muscle. We show for the first time that ARC is expressed in arterial smooth muscle cells of the pulmonary vasculature and is markedly upregulated in several experimental models of PH. In this study, we test the hypothesis that ARC expression is essential for the development of chronic hypoxia-induced PH. METHODS AND RESULTS: Experiments in which cells or mice were rendered ARC-deficient revealed that ARC not only protected pulmonary arterial smooth muscle cells from hypoxia-induced death, but also facilitated growth factor-induced proliferation and hypertrophy and hypoxia-induced downregulation of selective voltage-gated potassium channels, the latter a hallmark of the syndrome in humans. Moreover, ARC-deficient mice exhibited diminished vascular remodeling, increased apoptosis, and decreased proliferation in response to chronic hypoxia, resulting in marked protection from PH in vivo. Patients with PH have significantly increased ARC expression not only in remodeled vessels but also in the lumen-occluding lesions associated with severe disease. CONCLUSIONS: These data show that ARC, previously unlinked to pulmonary hypertension, is a critical determinant of vascular remodeling in this syndrome. |Animals [MESH] |Apoptosis Regulatory Proteins/genetics/*metabolism [MESH] |Cell Death/physiology [MESH] |Cell Division/physiology [MESH] |Cells, Cultured [MESH] |Chronic Disease [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Hypertension, Pulmonary/*metabolism/pathology/*physiopathology [MESH] |Hypoxia/*metabolism/pathology/*physiopathology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Muscle Proteins/genetics/*metabolism [MESH] |Muscle, Smooth, Vascular/cytology/physiology [MESH] |Potassium Channels, Voltage-Gated/genetics/physiology [MESH] |Pulmonary Circulation/physiology [MESH] |Rats [MESH] |Up-Regulation/physiology [MESH]A critical role for the protein apoptosis repressor with caspase recru(epmc).pdf DeepDyve Pubget Overpricing