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10.1074/jbc.M115.668061

http://scihub22266oqcxt.onion/10.1074/jbc.M115.668061
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suck abstract from ncbi


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pmid26260795      J+Biol+Chem 2015 ; 290 (39): 23826-37
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  • Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris* #MMPMID26260795
  • Chen Y; Chernyavsky A; Webber RJ; Grando SA; Wang PH
  • J Biol Chem 2015[Sep]; 290 (39): 23826-37 PMID26260795show ga
  • Background: Patients with pemphigus vulgaris develop antibodies to both cell adhesion molecules and intracellular proteins.Results: On the keratinocyte cell membrane, pemphigus autoantibodies form complexes with FcRn internalizing and trafficking them to mitochondria.Conclusion: The pathogenic role of antimitochondrial autoantibodies is complementary to that of anti-desmoglein autoantibodies, because both are required to disrupt the epidermal barrier.Significance: FcRn represents a common acceptor protein for internalization of autoantibodies to intracellular proteins.
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