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10.1161/CIRCULATIONAHA.115.016006

http://scihub22266oqcxt.onion/10.1161/CIRCULATIONAHA.115.016006
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C4582425!4582425!26371236
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suck abstract from ncbi

pmid26371236      Circulation 2015 ; 132 (11): 1038-45
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  • Drug Therapy for Heart Valve Diseases #MMPMID26371236
  • Borer JS; Sharma A
  • Circulation 2015[Sep]; 132 (11): 1038-45 PMID26371236show ga
  • Valvular heart diseases (VHDs) are progressive. When not caused by acute comorbidities they are generally characterized by long asymptomatic phases during which hemodynamic severity may progress leading to morbidity and mortality. Treatment depends on VHD type and severity but when severe and symptomatic, usually involves mechanical intervention. Asymptomatic patients, and those who lack objective descriptors associated with high risk, are closely observed clinically with optimization of associated cardiovascular risk factors until surgical indications develop. Though often prescribed based on theory, no rigorous evidence supports pharmacological therapy in most chronic situations though drugs may be appropriate in acute valvular diseases, or as a bridge to surgery in severely decompensated patients. Herein, we examine evidence supporting drug use for chronic VHDs.
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