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10.1242/dmm.019950 http://scihub22266oqcxt.onion/10.1242/dmm.019950 C4582103!4582103!26183212     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dis+Model+Mech 2015 ; 8 (9): 1037-46 Nephropedia Template TP {{tp|p=26183212|t=2015. Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis |pdf=|usr=}}{{26183212}} gab.com Text Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis JO: Dis Model Mech http://www.kidney.de/pget.php?&tw=1&pmid=26183212 #FOAvip Contrasting data exist on the effect of gender and menopause on the susceptibility, development and liver damage progression in non-alcoholic fatty liver disease (NAFLD). Our aim was to assess whether menopause is associated with the severity of liver fibrosis in individuals with NAFLD and to explore the issue of ovarian senescence in experimental liver steatosis in zebrafish. In 244 females and age-matched males with biopsy-proven NAFLD, we assessed anthropometric, biochemical and metabolic features, including menopausal status (self-reported); liver biopsy was scored according to ?The Pathology Committee of the NASH Clinical Research Network?. Young and old male and female zebrafish were fed for 24?weeks with a high-calorie diet. Weekly body mass index (BMI), histopathological examination and quantitative real-time PCR analysis on genes involved in lipid metabolism, inflammation and fibrosis were performed. In the entire cohort, at multivariate logistic regression, male gender [odds ratio (OR): 1.408, 95% confidence interval (95% CI): 0.779-2.542, P=0.25] vs women at reproductive age was not associated with F2-F4 fibrosis, whereas a trend was observed for menopause (OR: 1.752, 95% CI: 0.956-3.208, P=0.06). In women, menopause (OR: 2.717, 95% CI: 1.020-7.237, P=0.04) was independently associated with F2-F4 fibrosis. Similarly, in overfed zebrafish, old female fish with failing ovarian function [as demonstrated by extremely low circulating estradiol levels (1.4±0.1?pg/µl) and prevailing presence of atretic follicles in the ovaries] developed massive steatosis and substantial fibrosis (comparable with that occurring in males), whereas young female fish developed less steatosis and were totally protected from the development of fibrosis. Ovarian senescence significantly increases the risk of fibrosis severity both in humans with NAFLD and in zebrafish with experimental steatosis. Twit Text FOAVip Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis ????Dis Model Mech http://www.kidney.de/pget.php?&tw=1&pmid=26183212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26183212 #FOAvip English Wikipedia <ref>{{Cite pmid|26183212}}</ref> Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis #MMPMID26183212 Turola E; Petta S; Vanni E; Milosa F; Valenti L; Critelli R; Miele L; Maccio L; Calvaruso V; Fracanzani AL; Bianchini M; Raos N; Bugianesi E; Mercorella S; Di Giovanni M; Craxì A; Fargion S; Grieco A; Cammà C; Cotelli F; Villa E Dis Model Mech 2015[Sep]; 8 (9): 1037-46 PMID26183212show ga Contrasting data exist on the effect of gender and menopause on the susceptibility, development and liver damage progression in non-alcoholic fatty liver disease (NAFLD). Our aim was to assess whether menopause is associated with the severity of liver fibrosis in individuals with NAFLD and to explore the issue of ovarian senescence in experimental liver steatosis in zebrafish. In 244 females and age-matched males with biopsy-proven NAFLD, we assessed anthropometric, biochemical and metabolic features, including menopausal status (self-reported); liver biopsy was scored according to ?The Pathology Committee of the NASH Clinical Research Network?. Young and old male and female zebrafish were fed for 24?weeks with a high-calorie diet. Weekly body mass index (BMI), histopathological examination and quantitative real-time PCR analysis on genes involved in lipid metabolism, inflammation and fibrosis were performed. In the entire cohort, at multivariate logistic regression, male gender [odds ratio (OR): 1.408, 95% confidence interval (95% CI): 0.779-2.542, P=0.25] vs women at reproductive age was not associated with F2-F4 fibrosis, whereas a trend was observed for menopause (OR: 1.752, 95% CI: 0.956-3.208, P=0.06). In women, menopause (OR: 2.717, 95% CI: 1.020-7.237, P=0.04) was independently associated with F2-F4 fibrosis. Similarly, in overfed zebrafish, old female fish with failing ovarian function [as demonstrated by extremely low circulating estradiol levels (1.4±0.1?pg/µl) and prevailing presence of atretic follicles in the ovaries] developed massive steatosis and substantial fibrosis (comparable with that occurring in males), whereas young female fish developed less steatosis and were totally protected from the development of fibrosis. Ovarian senescence significantly increases the risk of fibrosis severity both in humans with NAFLD and in zebrafish with experimental steatosis. äOvarian senescence increases liver fibrosis in humans and zebrafish wi(epmc).pdf DeepDyve Pubget Overpricing