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10.1016/j.celrep.2015.08.021 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.08.021 C4581983!4581983!26344774     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 12 (11): 1740-7 Nephropedia Template TP {{tp|p=26344774|t=2015. Krüppel expression levels are maintained through compensatory evolution of shadow enhancers |pdf=|usr=}}{{26344774}} gab.com Text Krüppel expression levels are maintained through compensatory evolution of shadow enhancers JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26344774 #FOAvip Many developmental genes are controlled by shadow enhancers, pairs of enhancers that drive overlapping expression patterns. We hypothesized that compensatory evolution can maintain the total expression of a gene while individual shadow enhancers diverge between species. To test this hypothesis, we analyzed expression driven by orthologous pairs of shadow enhancers from Drosophila melanogaster, Drosophila yakuba, and Drosophila pseudoobscura that control expression of Krüppel, a transcription factor that patterns the anterior-posterior axis of blastoderm embryos. We find that the expression driven by the pair of enhancers is conserved between these three species, but expression levels driven by the individual enhancers are not. Using sequence analysis and experimental perturbation, we show that each shadow enhancer is activated by different transcription factors. These results support the hypothesis that compensatory evolution can occur between shadow enhancers, which has implications for mechanistic and evolutionary studies of gene regulation. Twit Text FOAVip Krüppel expression levels are maintained through compensatory evolution of shadow enhancers ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26344774 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26344774 #FOAvip English Wikipedia <ref>{{Cite pmid|26344774}}</ref> Krüppel expression levels are maintained through compensatory evolution of shadow enhancers #MMPMID26344774 Wunderlich Z; Bragdon MD; Vincent BJ; White JA; Estrada J; DePace AH Cell Rep 2015[Sep]; 12 (11): 1740-7 PMID26344774show ga Many developmental genes are controlled by shadow enhancers, pairs of enhancers that drive overlapping expression patterns. We hypothesized that compensatory evolution can maintain the total expression of a gene while individual shadow enhancers diverge between species. To test this hypothesis, we analyzed expression driven by orthologous pairs of shadow enhancers from Drosophila melanogaster, Drosophila yakuba, and Drosophila pseudoobscura that control expression of Krüppel, a transcription factor that patterns the anterior-posterior axis of blastoderm embryos. We find that the expression driven by the pair of enhancers is conserved between these three species, but expression levels driven by the individual enhancers are not. Using sequence analysis and experimental perturbation, we show that each shadow enhancer is activated by different transcription factors. These results support the hypothesis that compensatory evolution can occur between shadow enhancers, which has implications for mechanistic and evolutionary studies of gene regulation. äKrüppel expression levels are maintained through compensatory evolutio(epmc).pdf DeepDyve Pubget Overpricing