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2015 ; 9
(9-10
): E589-93
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Collecting (Bellini) duct carcinoma: A clinical study of a rare tumour and review
of the literature
#MMPMID26425219
Ciszewski S
; Jakimów A
; Smolska-Ciszewska B
Can Urol Assoc J
2015[Sep]; 9
(9-10
): E589-93
PMID26425219
show ga
INTRODUCTION: We report our 15-year experience of Collecting (Bellini) duct
carcinoma (CDC). We retrospectively analyzed patient and tumour characteristics,
clinical manifestations, surgical techniques, clinical outcomes, and salvage
therapies. METHODS: From January 1999 to December 2013, 1042 patients underwent
surgical resection of renal neoplasm. We examined all renal tumors and identified
10 cases (0.96%) of CDC. RESULTS: The study group included 8 men and 2 women,
with a median age of 62.5 years. Of these 10 patients, 9 were symptomatic (90%).
All patients were treated with open nephrectomy. The mean tumour size was 5.7 cm.
The pathologic stages were distributed as follows: pT1b in 2 patients (20%); pT2a
in 1 patient (10%); pT3a in 3 patients (30%); and pT3b in 4 patients (40%).
Grading was assessed according to Fuhrman scale as follows: grade II in 1 patient
(10%); grade III in 3 patients (30%); grade IV in 5 patients (50%); undetermined
grade in 1 patient (10%). Four patients (40%) relapsed locally. The median time
of local recurrence was 4.9 months. Distant metastases occurred in 9 patients
(90%): 4/9 at the time of diagnosis and 5/9 after nephrectomy. The median time of
distant metastases after surgery was 8.1 months. Six patients received
chemotherapy (gemcitabine plus platinum salts). Radiotherapy was performed in 5
patients. One patient had surgery because of local recurrence and 2 patients were
irradiated in the area of the local recurrence. The median overall survival was
7.6 months, and only 2 patients survived more than 2 years after the nephrectomy.
CONCLUSIONS: CDCs of the kidney are aggressive and they have a low survival rate.
All patients in our study experienced a relapse of their disease. Local
recurrence preceded distant metastases. Results of salvage treatments were poor.
free
free
free
