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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Stem+Cells 2011 ; 29 (6): 920-7 Nephropedia Template TP
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Mesenchymal Stem Cell Tumor-Homing: Detection Methods in Disease Model Systems #MMPMID21557390
Reagan MR; Kaplan DL
Stem Cells 2011[Jun]; 29 (6): 920-7 PMID21557390show ga
Despite the decline in U.S. cancer incidence and mortality rates, cancer remains the number one cause of death for people under the age of 85 and one in four people in the US will die of cancer, mainly due to metastasis1. Recently, interest in mesenchymal stem cell (MSC) tumor-homing has led to inquires into: 1) why MSCs home to tumors, 2) what the inherent pro- and anti-tumor consequences are, and 3) how to best capitalize on MSC tumor-homing for cell-based diagnostics and therapy. Here these questions are reviewed and method for addressing them using animal models and tracking methodologies (or, synonymously, detection methodologies) are discussed. First, MSCs in a regenerative and tumor-homing context are reviewed, followed by MSC delivery and genetic labeling methods for tissue model systems. Lastly, the use of the non-optical methods MRI (magnetic resonance imaging), PET (positron emission tomography) and SPECT (single photon emission computed tomography), along with optical methods, fluorescence imaging and BLI (bioluminescent imaging), are reviewed related to tracking MSCs within disease model settings. The benefits and drawbacks of each detection method in animal models is reviewed along with the utility of each for therapeutic use.