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10.3892/mmr.2015.4069 http://scihub22266oqcxt.onion/10.3892/mmr.2015.4069 C4581808!4581808 !26165998     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26165998 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2015 ; 12 (4 ): 4895-900 Nephropedia Template TP {{tp|p=26165998 |t=2015. Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70 |pdf=|usr=}}{{26165998 }} gab.com Text Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70 JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=26165998 #FOAvip Increasing evidence has demonstrated that the heat shock protein 70 (HSP70) gene may be closely associated with tissue fibrosis; however, the association between HSP70 and liver fibrosis remains to be fully elucidated. The present study hypothesized that geranylgeranylacetone (GGA) exerts beneficial effects on liver fibrosis though upregulation of the expression of HSP70. Liver fibrosis was induced in rats using carbon tetrachloride (CCl4). The rats were subsequently divided into three groups: Control group, CCl4 model group and CCl4 model + GGA group. Liver fibrosis in the rats was evaluated using hematoxylin and eosin staining, Masson's trichrome staining and Sirius red staining. The levels of serum alanine aminotransferase, aspartate aminotransferase and total bilirubin were determined using an automated biochemistry analyzer. The levels of total hepatic hydroxyproline were also determined. The expression levels of ??smooth muscle actin (??SMA) and transforming growth factor??1 (TGF??1) were determined using immunofluorescence staining and western blotting, and the protein expression levels of HSP70 were determined using western blotting. The CCl4?induced rats exhibited liver fibrosis, increased hydroxyproline content, impaired liver function, upregulated expression levels of the ??SMA and TGF??1 pro?fibrogenic proteins, and increased expression of HSP70, compared with the control group. These changes were attenuated by treatment with GGA. These results demonstrated that GGA exerted beneficial effects in CCl4?induced liver fibrosis via upregulating the expression of HSP70. Twit Text FOAVip Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70 ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=26165998 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26165998 #FOAvip English Wikipedia <ref>{{Cite pmid|26165998 }}</ref> Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70 #MMPMID26165998 He W ; Zhuang Y ; Wang L ; Qi L ; Chen B ; Wang M ; Shao D ; Chen J Mol Med Rep 2015[Oct]; 12 (4 ): 4895-900 PMID26165998 show ga Increasing evidence has demonstrated that the heat shock protein 70 (HSP70) gene may be closely associated with tissue fibrosis; however, the association between HSP70 and liver fibrosis remains to be fully elucidated. The present study hypothesized that geranylgeranylacetone (GGA) exerts beneficial effects on liver fibrosis though upregulation of the expression of HSP70. Liver fibrosis was induced in rats using carbon tetrachloride (CCl4). The rats were subsequently divided into three groups: Control group, CCl4 model group and CCl4 model + GGA group. Liver fibrosis in the rats was evaluated using hematoxylin and eosin staining, Masson's trichrome staining and Sirius red staining. The levels of serum alanine aminotransferase, aspartate aminotransferase and total bilirubin were determined using an automated biochemistry analyzer. The levels of total hepatic hydroxyproline were also determined. The expression levels of ??smooth muscle actin (??SMA) and transforming growth factor??1 (TGF??1) were determined using immunofluorescence staining and western blotting, and the protein expression levels of HSP70 were determined using western blotting. The CCl4?induced rats exhibited liver fibrosis, increased hydroxyproline content, impaired liver function, upregulated expression levels of the ??SMA and TGF??1 pro?fibrogenic proteins, and increased expression of HSP70, compared with the control group. These changes were attenuated by treatment with GGA. These results demonstrated that GGA exerted beneficial effects in CCl4?induced liver fibrosis via upregulating the expression of HSP70. |Actins/metabolism [MESH] |Alanine Transaminase/blood [MESH] |Animals [MESH] |Aspartate Aminotransferases/blood [MESH] |Bilirubin/blood [MESH] |Carbon Tetrachloride [MESH] |Disease Models, Animal [MESH] |Diterpenes/*pharmacology [MESH] |HSP70 Heat-Shock Proteins/genetics/*metabolism [MESH] |Hydroxyproline/metabolism [MESH] |Liver Cirrhosis/chemically induced/*drug therapy [MESH] |Liver/metabolism [MESH] |Male [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Transforming Growth Factor beta1/metabolism [MESH]Geranylgeranylacetone attenuates hepatic fibrosis by increasing the ex(epmc).pdf DeepDyve Pubget Overpricing