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10.4161/21541272.2014.944014

http://scihub22266oqcxt.onion/10.4161/21541272.2014.944014
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C4581346!4581346!25483404
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suck abstract from ncbi


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pmid25483404      Transcription 2014 ; 5 (4): ä
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  • Long non-coding RNAs as emerging regulators of differentiation, development, and disease #MMPMID25483404
  • Dey BK; Mueller AC; Dutta A
  • Transcription 2014[]; 5 (4): ä PMID25483404show ga
  • A significant portion of the mammalian genome encodes numerous transcripts that are not translated into proteins, termed long non-coding RNAs. Initial studies identifying long non-coding RNAs inferred these RNA sequences were a consequence of transcriptional noise or promiscuous RNA polymerase II activity. However, the last decade has seen a revolution in the understanding of regulation and function of long non-coding RNAs. Now it has become apparent that long non-coding RNAs play critical roles in a wide variety of biological processes. In this review, we describe the current understanding of long non-coding RNA-mediated regulation of cellular processes: differentiation, development, and disease.
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