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10.3390/ijms160818825 http://scihub22266oqcxt.onion/10.3390/ijms160818825 C4581274!4581274 !26274951     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26274951 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2015 ; 16 (8 ): 18825-35 Nephropedia Template TP {{tp|p=26274951 |t=2015. Osteoclast Differentiation Is Impaired in a Subgroup of SLE Patients and Correlates Inversely with Mycophenolate Mofetil Treatment |pdf=|usr=}}{{26274951 }} gab.com Text Osteoclast Differentiation Is Impaired in a Subgroup of SLE Patients and Correlates Inversely with Mycophenolate Mofetil Treatment JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26274951 #FOAvip Osteoporosis can arise in systemic lupus erythematosus (SLE) patients secondary to medication and/or chronic inflammation. To analyze if patients with SLE have phenotypically-impaired osteoclastogenesis, we differentiated ex vivo monocytes from 72 SLE patients and 15 healthy individuals into osteoclasts followed by TRAP staining and counting. We identified a subgroup of SLE patients (45%) with a significantly impaired osteoclast differentiation, relative to the other SLE patients or healthy individuals (OR 11.2; 95% CI 1.4-89.9). A review of medication indicated that patients with osteoclast counts equal to healthy donors were significantly more likely to be treated with mycophenolate mofetil (MMF) compared to patients with impaired osteoclastogenesis. We analyzed expression of RANKL and the MMF target genes IMPDH1 and IMPDH2 in osteoclasts by qPCR, but detected no difference. Since MMF might influence interferon-? (IFN?) and -? (IFN?) we measured serum IFN? and IFN? levels. Patients with very low osteoclast counts also had comparably higher IFN? serum levels than patients with normal osteoclast counts. We conclude that in vitro osteoclastogenesis is impaired in a subgroup of SLE patients. This correlates inversely with MMF treatment and high IFN? serum levels. Further observational study will be required to determine whether this translates into a clinically meaningful effect. Twit Text FOAVip Osteoclast Differentiation Is Impaired in a Subgroup of SLE Patients and Correlates Inversely with Mycophenolate Mofetil Treatment ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26274951 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26274951 #FOAvip English Wikipedia <ref>{{Cite pmid|26274951 }}</ref> Osteoclast Differentiation Is Impaired in a Subgroup of SLE Patients and Correlates Inversely with Mycophenolate Mofetil Treatment #MMPMID26274951 Fürnrohr BG ; Rhodes B ; Munoz LE ; Weiß K ; Vyse TJ ; Schett G Int J Mol Sci 2015[Aug]; 16 (8 ): 18825-35 PMID26274951 show ga Osteoporosis can arise in systemic lupus erythematosus (SLE) patients secondary to medication and/or chronic inflammation. To analyze if patients with SLE have phenotypically-impaired osteoclastogenesis, we differentiated ex vivo monocytes from 72 SLE patients and 15 healthy individuals into osteoclasts followed by TRAP staining and counting. We identified a subgroup of SLE patients (45%) with a significantly impaired osteoclast differentiation, relative to the other SLE patients or healthy individuals (OR 11.2; 95% CI 1.4-89.9). A review of medication indicated that patients with osteoclast counts equal to healthy donors were significantly more likely to be treated with mycophenolate mofetil (MMF) compared to patients with impaired osteoclastogenesis. We analyzed expression of RANKL and the MMF target genes IMPDH1 and IMPDH2 in osteoclasts by qPCR, but detected no difference. Since MMF might influence interferon-? (IFN?) and -? (IFN?) we measured serum IFN? and IFN? levels. Patients with very low osteoclast counts also had comparably higher IFN? serum levels than patients with normal osteoclast counts. We conclude that in vitro osteoclastogenesis is impaired in a subgroup of SLE patients. This correlates inversely with MMF treatment and high IFN? serum levels. Further observational study will be required to determine whether this translates into a clinically meaningful effect. |*Cell Differentiation [MESH] |Adrenal Cortex Hormones/therapeutic use [MESH] |Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use [MESH] |Blood Cell Count [MESH] |Case-Control Studies [MESH] |Cell Count [MESH] |Female [MESH] |Gene Expression Regulation/drug effects [MESH] |Humans [MESH] |IMP Dehydrogenase/genetics/metabolism [MESH] |Interferon-alpha/blood/metabolism [MESH] |Lupus Erythematosus, Systemic/blood/*drug therapy/genetics/*pathology [MESH] |Male [MESH] |Mycophenolic Acid/*analogs & derivatives/therapeutic use [MESH] |Osteoclasts/*cytology/*pathology [MESH] |Receptor Activator of Nuclear Factor-kappa B/genetics/metabolism [MESH]Osteoclast Differentiation Is Impaired in a Subgroup of SLE Patients a(epmc).pdf DeepDyve Pubget Overpricing