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10.3390/ijms160818683 http://scihub22266oqcxt.onion/10.3390/ijms160818683 C4581266!4581266!26270565     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2015 ; 16 (8): 18683-713 Nephropedia Template TP {{tp|p=26270565|t=2015. Scanning for Therapeutic Targets within the Cytokine Network of Idiopathic Inflammatory Myopathies |pdf=|usr=}}{{26270565}} gab.com Text Scanning for Therapeutic Targets within the Cytokine Network of Idiopathic Inflammatory Myopathies JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26270565 #FOAvip The idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of chronic disorders that include dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM). They represent distinct pathological entities that, most often, share predominant inflammation in muscle tissue. Many of the immunopathogenic processes behind the IIM remain poorly understood, but the crucial role of cytokines as essential regulators of the intramuscular build-up of inflammation is undisputed. This review describes the extensive cytokine network within IIM muscle, characterized by strong expression of Tumor Necrosis Factors (TNF?, LT?, BAFF), Interferons (IFN?/?/?), Interleukins (IL-1/6/12/15/18/23) and Chemokines (CXCL9/10/11/13, CCL2/3/4/8/19/21). Current therapeutic strategies and the exploration of potential disease modifying agents based on manipulation of the cytokine network are provided. Reported responses to anti-TNF? treatment in IIM are conflicting and new onset DM/PM has been described after administration of anti-TNF? agents to treat other diseases, pointing to the complex effects of TNF? neutralization. Treatment with anti-IFN? has been shown to suppress the IFN type 1 gene signature in DM/PM patients and improve muscle strength. Beneficial effects of anti-IL-1 and anti-IL-6 therapy have also been reported. Cytokine profiling in IIM aids the development of therapeutic strategies and provides approaches to subtype patients for treatment outcome prediction. Twit Text FOAVip Scanning for Therapeutic Targets within the Cytokine Network of Idiopathic Inflammatory Myopathies ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26270565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26270565 #FOAvip English Wikipedia <ref>{{Cite pmid|26270565}}</ref> Scanning for Therapeutic Targets within the Cytokine Network of Idiopathic Inflammatory Myopathies #MMPMID26270565 De Paepe B; Zschüntzsch J Int J Mol Sci 2015[Aug]; 16 (8): 18683-713 PMID26270565show ga The idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of chronic disorders that include dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM). They represent distinct pathological entities that, most often, share predominant inflammation in muscle tissue. Many of the immunopathogenic processes behind the IIM remain poorly understood, but the crucial role of cytokines as essential regulators of the intramuscular build-up of inflammation is undisputed. This review describes the extensive cytokine network within IIM muscle, characterized by strong expression of Tumor Necrosis Factors (TNF?, LT?, BAFF), Interferons (IFN?/?/?), Interleukins (IL-1/6/12/15/18/23) and Chemokines (CXCL9/10/11/13, CCL2/3/4/8/19/21). Current therapeutic strategies and the exploration of potential disease modifying agents based on manipulation of the cytokine network are provided. Reported responses to anti-TNF? treatment in IIM are conflicting and new onset DM/PM has been described after administration of anti-TNF? agents to treat other diseases, pointing to the complex effects of TNF? neutralization. Treatment with anti-IFN? has been shown to suppress the IFN type 1 gene signature in DM/PM patients and improve muscle strength. Beneficial effects of anti-IL-1 and anti-IL-6 therapy have also been reported. Cytokine profiling in IIM aids the development of therapeutic strategies and provides approaches to subtype patients for treatment outcome prediction. äScanning for Therapeutic Targets within the Cytokine Network of Idiopa(epmc).pdf DeepDyve Pubget Overpricing