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10.3390/ijms160818348

http://scihub22266oqcxt.onion/10.3390/ijms160818348
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C4581249!4581249!26262608
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suck abstract from ncbi

pmid26262608      Int+J+Mol+Sci 2015 ; 16 (8): 18348-67
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  • Overview of Nrf2 as Therapeutic Target in Epilepsy #MMPMID26262608
  • Carmona-Aparicio L; Pérez-Cruz C; Zavala-Tecuapetla C; Granados-Rojas L; Rivera-Espinosa L; Montesinos-Correa H; Hernández-Damián J; Pedraza-Chaverri J; Sampieri AI; Coballase-Urrutia E; Cárdenas-Rodríguez N
  • Int J Mol Sci 2015[Aug]; 16 (8): 18348-67 PMID26262608show ga
  • Oxidative stress is a biochemical state of imbalance in the production of reactive oxygen and nitrogen species and antioxidant defenses. It is involved in the physiopathology of degenerative and chronic neuronal disorders, such as epilepsy. Experimental evidence in humans and animals support the involvement of oxidative stress before and after seizures. In the past few years, research has increasingly focused on the molecular pathways of this process, such as that involving transcription factor nuclear factor E2-related factor 2 (Nrf2), which plays a central role in the regulation of antioxidant response elements (ARE) and modulates cellular redox status. The aim of this review is to present experimental evidence on the role of Nrf2 in this neurological disorder and to further determine the therapeutic impact of Nrf2 in epilepsy.
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