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10.3390/ijms160817303 http://scihub22266oqcxt.onion/10.3390/ijms160817303 C4581194!4581194!26230688     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2015 ; 16 (8): 17303-14 Nephropedia Template TP {{tp|p=26230688|t=2015. Distribution of ADAT-Dependent Codons in the Human Transcriptome |pdf=|usr=}}{{26230688}} gab.com Text Distribution of ADAT-Dependent Codons in the Human Transcriptome JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26230688 #FOAvip Nucleotide modifications in the anticodons of transfer RNAs (tRNA) play a central role in translation efficiency, fidelity, and regulation of translation, but, for most of these modifications, the details of their function remain unknown. The heterodimeric adenosine deaminases acting on tRNAs (ADAT2-ADAT3, or ADAT) are enzymes present in eukaryotes that convert adenine (A) to inosine (I) in the first anticodon base (position 34) by hydrolytic deamination. To explore the influence of ADAT activity on mammalian translation, we have characterized the human transcriptome and proteome in terms of frequency and distribution of ADAT-related codons. Eight different tRNAs can be modified by ADAT and, once modified, these tRNAs will recognize NNC, NNU and NNA codons, but not NNG codons. We find that transcripts coding for proteins highly enriched in these eight amino acids (ADAT-aa) are specifically enriched in NNC, NNU and NNA codons. We also show that the proteins most enriched in ADAT-aa are composed preferentially of threonine, alanine, proline, and serine (TAPS). We propose that the enrichment in ADAT-codons in these proteins is due to the similarities in the codons that correspond to TAPS. Twit Text FOAVip Distribution of ADAT-Dependent Codons in the Human Transcriptome ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26230688 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26230688 #FOAvip English Wikipedia <ref>{{Cite pmid|26230688}}</ref> Distribution of ADAT-Dependent Codons in the Human Transcriptome #MMPMID26230688 Rafels-Ybern Ŕ; Attolini CSO; Ribas de Pouplana L Int J Mol Sci 2015[Aug]; 16 (8): 17303-14 PMID26230688show ga Nucleotide modifications in the anticodons of transfer RNAs (tRNA) play a central role in translation efficiency, fidelity, and regulation of translation, but, for most of these modifications, the details of their function remain unknown. The heterodimeric adenosine deaminases acting on tRNAs (ADAT2-ADAT3, or ADAT) are enzymes present in eukaryotes that convert adenine (A) to inosine (I) in the first anticodon base (position 34) by hydrolytic deamination. To explore the influence of ADAT activity on mammalian translation, we have characterized the human transcriptome and proteome in terms of frequency and distribution of ADAT-related codons. Eight different tRNAs can be modified by ADAT and, once modified, these tRNAs will recognize NNC, NNU and NNA codons, but not NNG codons. We find that transcripts coding for proteins highly enriched in these eight amino acids (ADAT-aa) are specifically enriched in NNC, NNU and NNA codons. We also show that the proteins most enriched in ADAT-aa are composed preferentially of threonine, alanine, proline, and serine (TAPS). We propose that the enrichment in ADAT-codons in these proteins is due to the similarities in the codons that correspond to TAPS. äDistribution of ADAT-Dependent Codons in the Human Transcriptome (epmc).pdf DeepDyve Pubget Overpricing