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10.3390/ijms160816953 http://scihub22266oqcxt.onion/10.3390/ijms160816953 C4581178!4581178 !26225955     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26225955 &cmd=llinks): Failed to open stream: HTTP request failed! 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MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers |pdf=|usr=}}{{26225955 }} gab.com Text MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26225955 #FOAvip MicroRNAs control the differentiation and function of B cells, which are considered key elements in the pathogenesis of systemic lupus erythematosus (SLE). However, a common micro(mi)RNA signature has not emerged since published data includes patients of variable ethnic background, type of disease, and organ involvement, as well as heterogeneous cell populations. Here, we aimed at identifying a miRNA signature of purified B cells from renal and non-renal severe SLE patients of Latin American background, a population known to express severe disease. Genome-wide miRNA expression analyses were performed on naive and memory B cells and revealed two categories of miRNA signatures. The first signature represents B cell subset-specific miRNAs deregulated in SLE: 11 and six miRNAs discriminating naive and memory B cells of SLE patients from healthy controls (HC), respectively. Whether the miRNA was up or down-regulated in memory B cells as compared with naive B cells in HC, this difference was abolished in SLE patients, and vice versa. The second signature identifies six miRNAs associated with specific pathologic features affecting renal outcome, providing a further understanding for SLE pathogenesis. Overall, the present work provided promising biomarkers in molecular diagnostics for disease severity as well as potential new targets for therapeutic intervention in SLE. Twit Text FOAVip MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26225955 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26225955 #FOAvip English Wikipedia <ref>{{Cite pmid|26225955 }}</ref> MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers #MMPMID26225955 Duroux-Richard I ; Cuenca J ; Ponsolles C ; Piņeiro AB ; Gonzalez F ; Roubert C ; Areny R ; Chea R ; Pefaur J ; Pers YM ; Figueroa FE ; Jorgensen C ; Khoury M ; Apparailly F Int J Mol Sci 2015[Jul]; 16 (8 ): 16953-65 PMID26225955 show ga MicroRNAs control the differentiation and function of B cells, which are considered key elements in the pathogenesis of systemic lupus erythematosus (SLE). However, a common micro(mi)RNA signature has not emerged since published data includes patients of variable ethnic background, type of disease, and organ involvement, as well as heterogeneous cell populations. Here, we aimed at identifying a miRNA signature of purified B cells from renal and non-renal severe SLE patients of Latin American background, a population known to express severe disease. Genome-wide miRNA expression analyses were performed on naive and memory B cells and revealed two categories of miRNA signatures. The first signature represents B cell subset-specific miRNAs deregulated in SLE: 11 and six miRNAs discriminating naive and memory B cells of SLE patients from healthy controls (HC), respectively. Whether the miRNA was up or down-regulated in memory B cells as compared with naive B cells in HC, this difference was abolished in SLE patients, and vice versa. The second signature identifies six miRNAs associated with specific pathologic features affecting renal outcome, providing a further understanding for SLE pathogenesis. Overall, the present work provided promising biomarkers in molecular diagnostics for disease severity as well as potential new targets for therapeutic intervention in SLE. |*Gene Expression Profiling [MESH] |Adult [MESH] |B-Lymphocyte Subsets/*metabolism [MESH] |Biomarkers/*metabolism [MESH] |Case-Control Studies [MESH] |Chile [MESH] |Cluster Analysis [MESH] |France [MESH] |Humans [MESH] |Lupus Erythematosus, Systemic/diagnosis/*genetics/*immunology [MESH] |Lupus Nephritis/diagnosis/genetics [MESH]MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus(epmc).pdf DeepDyve Pubget Overpricing