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10.1080/21565562.2015.1066476

http://scihub22266oqcxt.onion/10.1080/21565562.2015.1066476
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C4581073!4581073!26413414
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suck abstract from ncbi


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pmid26413414      Spermatogenesis 2015 ; 5 (2): ä
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  • Formins: Actin nucleators that regulate cytoskeletal dynamics during spermatogenesis #MMPMID26413414
  • Li N; Mruk DD; Tang EI; Wong CK; Lee WM; Silvestrini B; Cheng CY
  • Spermatogenesis 2015[May]; 5 (2): ä PMID26413414show ga
  • Formins are a growing class of actin nucleation proteins that promote the polymerization of actin microfilaments, forming long stretches of actin microfilaments to confer actin filament bundling in mammalian cells. As such, microfilament bundles can be formed in specific cellular domains, in particular in motile mammalian cells, such as filopodia. Since ectoplasmic specialization (ES), a testis-specific adherens junction (AJ), at the Sertoli cell-cell and Sertoli-spermatid interface is constituted by arrays of actin microfilament bundles, it is likely that formins are playing a significant physiological role on the homeostasis of ES during the epithelial cycle of spermatogenesis. In this Commentary, we provide a timely discussion on formin 1 which was recently shown to be a crucial regulator of actin microfilaments at the ES in the rat testis (Li N et al. Endocrinology, 2015, in press; DOI: 10.1210/en.2015-1161, PMID:25901598). We also highlight research that is needed to unravel the functional significance of formins in spermatogenesis.
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