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10.1016/j.clim.2013.12.001 http://scihub22266oqcxt.onion/10.1016/j.clim.2013.12.001 C4580910!4580910 !24434272     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24434272 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Immunol 2014 ; 150 (2 ): 184-91 Nephropedia Template TP {{tp|p=24434272 |t=2014. Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis |pdf=|usr=}}{{24434272 }} gab.com Text Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24434272 #FOAvip Hepatitis C cirrhosis is associated with a profound disappearance of memory B-cells. We sought to determine if this loss is associated with the expansion of the CD27(-)CD21(-) tissue-like memory B-cells with features of B-cell exhaustion. To this end, we quantified the frequency of CD27(-)CD21(-) B-cells in healthy, non-cirrhotic HCV-infected, and cirrhotic patients. We examined the expression of putative inhibitory receptors, the proliferative and immunoglobulin-secreting capacity of CD27/CD21-defined B-cell subsets upon B-cell receptor and/or CD40 stimulation. We found that CD27(-)CD21(-) B-cells are significantly increased in frequency relative to healthy donors in HCV-infected patients. CD27(-)CD21(-) B-cells were hypoproliferative relative to naïve and resting memory B-cells upon agonistic stimulation, but retained similar capacity for antibody secretion. CONCLUSION: CD27(-)CD21(-) tissue-like memory B-cells with exhausted proliferation circulate at increased frequency in cirrhotic and non-cirrhotic HCV-infected patients. This B-cell subset does not appear anergic, exhibiting immunoglobulin-secreting capacity on CD40 agonism indistinguishable from other CD27/CD21-defined B-cell subsets. Twit Text FOAVip Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24434272 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24434272 #FOAvip English Wikipedia <ref>{{Cite pmid|24434272 }}</ref> Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis #MMPMID24434272 Doi H ; Tanoue S ; Kaplan DE Clin Immunol 2014[Feb]; 150 (2 ): 184-91 PMID24434272 show ga Hepatitis C cirrhosis is associated with a profound disappearance of memory B-cells. We sought to determine if this loss is associated with the expansion of the CD27(-)CD21(-) tissue-like memory B-cells with features of B-cell exhaustion. To this end, we quantified the frequency of CD27(-)CD21(-) B-cells in healthy, non-cirrhotic HCV-infected, and cirrhotic patients. We examined the expression of putative inhibitory receptors, the proliferative and immunoglobulin-secreting capacity of CD27/CD21-defined B-cell subsets upon B-cell receptor and/or CD40 stimulation. We found that CD27(-)CD21(-) B-cells are significantly increased in frequency relative to healthy donors in HCV-infected patients. CD27(-)CD21(-) B-cells were hypoproliferative relative to naïve and resting memory B-cells upon agonistic stimulation, but retained similar capacity for antibody secretion. CONCLUSION: CD27(-)CD21(-) tissue-like memory B-cells with exhausted proliferation circulate at increased frequency in cirrhotic and non-cirrhotic HCV-infected patients. This B-cell subset does not appear anergic, exhibiting immunoglobulin-secreting capacity on CD40 agonism indistinguishable from other CD27/CD21-defined B-cell subsets. |Adult [MESH] |Aged [MESH] |Antibody Formation/immunology [MESH] |B-Lymphocyte Subsets/*immunology/metabolism [MESH] |Female [MESH] |Hepatitis C/complications/*immunology/metabolism [MESH] |Humans [MESH] |Immunophenotyping [MESH] |Liver Cirrhosis/complications/*immunology/metabolism [MESH] |Lymphocyte Activation/immunology [MESH] |Male [MESH] |Middle Aged [MESH] |Phenotype [MESH] |Receptors, Antigen, B-Cell/metabolism [MESH] |Receptors, Complement 3d/metabolism [MESH] |Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism [MESH]Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte popula(epmc).pdf DeepDyve Pubget Overpricing