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2015 ; 50
(9
): 657-70
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English Wikipedia
Ultrasound in Radiology: From Anatomic, Functional, Molecular Imaging to Drug
Delivery and Image-Guided Therapy
#MMPMID26200224
Klibanov AL
; Hossack JA
Invest Radiol
2015[Sep]; 50
(9
): 657-70
PMID26200224
show ga
During the past decade, ultrasound has expanded medical imaging well beyond the
"traditional" radiology setting: a combination of portability, low cost, and ease
of use makes ultrasound imaging an indispensable tool for radiologists as well as
for other medical professionals who need to obtain imaging diagnosis or guide a
therapeutic intervention quickly and efficiently. Ultrasound combines excellent
ability for deep penetration into soft tissues with very good spatial resolution,
with only a few exceptions (ie, those involving overlying bone or gas). Real-time
imaging (up to hundreds and thousands of frames per second) enables guidance of
therapeutic procedures and biopsies; characterization of the mechanical
properties of the tissues greatly aids with the accuracy of the procedures. The
ability of ultrasound to deposit energy locally brings about the potential for
localized intervention encompassing the following: tissue ablation, enhancing
penetration through the natural barriers to drug delivery in the body and
triggering drug release from carrier microparticles and nanoparticles. The use of
microbubble contrast agents brings the ability to monitor and quantify tissue
perfusion, and microbubble targeting with ligand-decorated microbubbles brings
the ability to obtain molecular biomarker information, that is, ultrasound
molecular imaging. Overall, ultrasound has become the most widely used imaging
modality in modern medicine; it will continue to grow and expand.
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