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2015 ; 10
(9
): e0138287
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gab.com Text
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English Wikipedia
PrePex Male Circumcision: Follow-Up and Outcomes during the First Two Years of
Implementation at the Rwanda Military Hospital
#MMPMID26398343
Ndagijimana A
; Mugenzi P
; Thomson DR
; Hedt-Gauthier B
; Condo JU
; Ngoga E
PLoS One
2015[]; 10
(9
): e0138287
PMID26398343
show ga
BACKGROUND: PrePex Male Circumcision (MC) has been demonstrated as an effective
and scalable strategy to prevent HIV infection in low- and middle-income
countries. This study describes the follow-up and outcomes of clients who
underwent PrePex MC between January 2011 and December 2012 with weekly follow-up
at the Rwanda Military Hospital, the first national hospital in Rwanda to adopt
PrePex. METHODS: Data on 570 clients age 21 to 54 were extracted from patient
records. We compared socio-demographic and clinical characteristics, the
operator's qualification, HIV status, pain before and after device removal,
urological status, device size and follow-up time between clients who were
formally discharged and those who defaulted. We reported bivariate associations
between each covariate and discharge status, number of people with adverse events
by discharge status, and time to formal discharge or defaulting using life table
methods. Data were entered into Epidata and analyzed with Stata v 13. RESULTS:
Among study participants, 96.5% were circumcised by non-physician operators,
85.4%were under 30 years, 98.9% were HIV-negative and 97.9% were without any
urological problems that could delay the healing time. Most (70.7%) defaulted
before formal discharge. Pain before (p<0.001) and after PrePex device removal (p
= 0.001) were associated with discharge status, although very few cases were
reported, and pain was more commonly missing among defaulters. Twenty-seven
adverse events were reported (7 formally discharged, 20 defaulters). Median
follow-up time was seven weeks among formally discharged and six weeks among
defaulters (p<0.001). CONCLUSION: Given that all socio-demographic and most
clinical characteristics were not associated with defaulting, we hypothesize that
clients stopped returning once they determined they were healed. We recommend
less frequent follow-up protocols to encourage clinical visits until formal
discharge. Based on these results and recommendations, we believe PrePex MC is a
practical circumcision strategy in Rwanda and in sub-Saharan Africa.