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The medial prefrontal cortex: coordinator of autonomic, neuroendocrine and
behavioural responses to stress
#MMPMID25737097
McKlveen JM
; Myers B
; Herman JP
J Neuroendocrinol
2015[Jun]; 27
(6
): 446-56
PMID25737097
show ga
Responding to real or potential threats in the environment requires the
coordination of autonomic, neuroendocrine and behavioural processes to promote
adaptation and survival. These diverging systems necessitate input from the
limbic forebrain to integrate and modulate functional output in accordance with
contextual demand. In the present review, we discuss the potential role of the
medial prefrontal cortex (mPFC) as a coordinator of behavioural and physiological
stress responses across multiple temporal and contextual domains. Furthermore, we
highlight converging evidence from rodent and human research indicating the
necessity of the mPFC for modulating physiological energetic systems to mobilise
or limit energetic resources as needed to ultimately promote behavioural
adaptation in the face of stress. We review the literature indicating that
glucocorticoids act as one of the primary messengers in the reallocation of
energetic resources having profound effects locally within the mPFC, as well as
shaping how the mPFC acts within a network of brain structures to modulate
responses to stress. Finally, we discuss how both rodent and human studies point
toward a critical role of the mPFC in the coordination of anticipatory responses
to stress and why this distinction is an important one to make in stress
neurobiology.
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