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2009 ; 109
(8
): 1094-104
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Atomic force microscopy: Unraveling the fundamental principles governing
secretion and membrane fusion in cells
#MMPMID19443122
Jena BP
Ultramicroscopy
2009[Jul]; 109
(8
): 1094-104
PMID19443122
show ga
The story of cell secretion and membrane fusion is as old as life itself. Without
these fundamental cellular processes known to occur in yeast to humans, life
would cease to exist. In the last 15 years, primarily using the atomic force
microscope, a detailed understanding of the molecular process and of the
molecular machinery and mechanism of secretion and membrane fusion in cells has
come to light. This has led to a paradigm shift in our understanding of the
underlying mechanism of cell secretion. The journey leading to the discovery of a
new cellular structure the 'porosome',-the universal secretory machinery in
cells, and the contributions of the AFM in our understanding of the general
molecular machinery and mechanism of cell secretion and membrane fusion, is
briefly discussed in this article.