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10.1128/JVI.01523-15 http://scihub22266oqcxt.onion/10.1128/JVI.01523-15 C4580178!4580178 !26223639     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26223639 &cmd=llinks): Failed to open stream: HTTP request failed! 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Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses |pdf=|usr=}}{{26223639 }} gab.com Text Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses JO: J Virol http://www.kidney.de/pget.php?&tw=1&pmid=26223639 #FOAvip Influenza viruses continue to present global threats to human health. Antigenic drift and shift, genetic reassortment, and cross-species transmission generate new strains with differences in epidemiology and clinical severity. We compared the temporal transcriptional responses of human dendritic cells (DC) to infection with two pandemic (A/Brevig Mission/1/1918, A/California/4/2009) and two seasonal (A/New Caledonia/20/1999, A/Texas/36/1991) H1N1 influenza viruses. Strain-specific response differences included stronger activation of NF-?B following infection with A/New Caledonia/20/1999 and a unique cluster of genes expressed following infection with A/Brevig Mission/1/1918. A common antiviral program showing strain-specific timing was identified in the early DC response and found to correspond with reported transcript changes in blood during symptomatic human influenza virus infection. Comparison of the global responses to the seasonal and pandemic strains showed that a dramatic divergence occurred after 4 h, with only the seasonal strains inducing widespread mRNA loss. IMPORTANCE: Continuously evolving influenza viruses present a global threat to human health; however, these host responses display strain-dependent differences that are incompletely understood. Thus, we conducted a detailed comparative study assessing the immune responses of human DC to infection with two pandemic and two seasonal H1N1 influenza strains. We identified in the immune response to viral infection both common and strain-specific features. Among the stain-specific elements were a time shift of the interferon-stimulated gene response, selective induction of NF-?B signaling by one of the seasonal strains, and massive RNA degradation as early as 4 h postinfection by the seasonal, but not the pandemic, viruses. These findings illuminate new aspects of the distinct differences in the immune responses to pandemic and seasonal influenza viruses. Twit Text FOAVip Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses ????J Virol http://www.kidney.de/pget.php?&tw=1&pmid=26223639 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26223639 #FOAvip English Wikipedia <ref>{{Cite pmid|26223639 }}</ref> Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses #MMPMID26223639 Hartmann BM ; Thakar J ; Albrecht RA ; Avey S ; Zaslavsky E ; Marjanovic N ; Chikina M ; Fribourg M ; Hayot F ; Schmolke M ; Meng H ; Wetmur J ; García-Sastre A ; Kleinstein SH ; Sealfon SC J Virol 2015[Oct]; 89 (20 ): 10190-205 PMID26223639 show ga Influenza viruses continue to present global threats to human health. Antigenic drift and shift, genetic reassortment, and cross-species transmission generate new strains with differences in epidemiology and clinical severity. We compared the temporal transcriptional responses of human dendritic cells (DC) to infection with two pandemic (A/Brevig Mission/1/1918, A/California/4/2009) and two seasonal (A/New Caledonia/20/1999, A/Texas/36/1991) H1N1 influenza viruses. Strain-specific response differences included stronger activation of NF-?B following infection with A/New Caledonia/20/1999 and a unique cluster of genes expressed following infection with A/Brevig Mission/1/1918. A common antiviral program showing strain-specific timing was identified in the early DC response and found to correspond with reported transcript changes in blood during symptomatic human influenza virus infection. Comparison of the global responses to the seasonal and pandemic strains showed that a dramatic divergence occurred after 4 h, with only the seasonal strains inducing widespread mRNA loss. IMPORTANCE: Continuously evolving influenza viruses present a global threat to human health; however, these host responses display strain-dependent differences that are incompletely understood. Thus, we conducted a detailed comparative study assessing the immune responses of human DC to infection with two pandemic and two seasonal H1N1 influenza strains. We identified in the immune response to viral infection both common and strain-specific features. Among the stain-specific elements were a time shift of the interferon-stimulated gene response, selective induction of NF-?B signaling by one of the seasonal strains, and massive RNA degradation as early as 4 h postinfection by the seasonal, but not the pandemic, viruses. These findings illuminate new aspects of the distinct differences in the immune responses to pandemic and seasonal influenza viruses. |*Pandemics [MESH] |Antigenic Variation [MESH] |Dendritic Cells/*immunology/virology [MESH] |Europe/epidemiology [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |History, 20th Century [MESH] |History, 21st Century [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Influenza A Virus, H1N1 Subtype/genetics/*immunology [MESH] |Influenza Pandemic, 1918-1919/*history [MESH] |Influenza, Human/*epidemiology/genetics/history/immunology [MESH] |Interferons/genetics/immunology [MESH] |Molecular Epidemiology [MESH] |NF-kappa B/genetics/immunology [MESH] |Reassortant Viruses/genetics/*immunology [MESH] |Recombination, Genetic [MESH] |Seasons [MESH] |Signal Transduction [MESH] |Time Factors [MESH]Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, a(epmc).pdf DeepDyve Pubget Overpricing