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10.1136/heartjnl-2014-307168 http://scihub22266oqcxt.onion/10.1136/heartjnl-2014-307168 C4580134!4580134 !26209334     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26209334 &cmd=llinks): Failed to open stream: HTTP request failed! 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Outcomes with prolonged clopidogrel therapy after coronary stenting in patients with chronic kidney disease |pdf=|usr=}}{{26209334 }} gab.com Text Outcomes with prolonged clopidogrel therapy after coronary stenting in patients with chronic kidney disease JO: Heart http://www.kidney.de/pget.php?&tw=1&pmid=26209334 #FOAvip OBJECTIVES: Patients with chronic kidney disease (CKD) are at high risk of death or myocardial infarction (MI) after percutaneous coronary interventions (PCI). We assessed whether prolonged dual antiplatelet therapy beyond the recommended 12?months may prevent adverse outcomes in patients with CKD receiving drug-eluting stents (DES) or bare-metal stents (BMS). METHODS: We studied all Veterans receiving PCI with BMS or first-generation DES in the Veterans Affairs (VA) Healthcare System between 2002 and 2006, classified by CKD (estimated glomerular filtration rate <60?mL/min) or normal renal function. We used landmark analyses from 12 months after PCI with Cox proportional hazards multivariable and propensity-adjusted models to assess the effect of prolonged clopidogrel (more than 12? months) versus 12 months or less after PCI on clinical outcomes from 1 year to 4?years after PCI. RESULTS: Of 23?042 eligible subjects receiving PCI, 4880 (21%) had CKD. Compared with normal renal function, patients with CKD had higher risks of death or MI 1-4?years after DES (21% vs 12%, HR=1.75; 95% CI 1.51 to 2.04) or BMS (28% vs 15%, HR=2.10; 95% CI 1.90 to 2.32). In patients with CKD receiving DES, clopidogrel use of more than 12 months after PCI was associated with lower risks of death or MI (18% vs 24%, HR=0.74; 95% CI 0.58 to 0.95), and death (15% vs 23%, HR=0.61; 95% CI 0.47 to 0.80), but had no effect on repeat revascularisation 1-4?years after PCI. CONCLUSIONS: In patients with CKD, prolonging clopidogrel beyond 12?months after PCI may decrease the risk of death or MI only in patients receiving first-generation DES. These results support a patient-tailored approach to prolonging clopidogrel after PCI. Twit Text FOAVip Outcomes with prolonged clopidogrel therapy after coronary stenting in patients with chronic kidney disease ????Heart http://www.kidney.de/pget.php?&tw=1&pmid=26209334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26209334 #FOAvip English Wikipedia <ref>{{Cite pmid|26209334 }}</ref> Outcomes with prolonged clopidogrel therapy after coronary stenting in patients with chronic kidney disease #MMPMID26209334 Siddiqi OK ; Smoot KJ ; Dufour AB ; Cho K ; Young M ; Gagnon DR ; Ly S ; Temiyasathit S ; Faxon DP ; Gaziano JM ; Kinlay S Heart 2015[Oct]; 101 (19 ): 1569-76 PMID26209334 show ga OBJECTIVES: Patients with chronic kidney disease (CKD) are at high risk of death or myocardial infarction (MI) after percutaneous coronary interventions (PCI). We assessed whether prolonged dual antiplatelet therapy beyond the recommended 12?months may prevent adverse outcomes in patients with CKD receiving drug-eluting stents (DES) or bare-metal stents (BMS). METHODS: We studied all Veterans receiving PCI with BMS or first-generation DES in the Veterans Affairs (VA) Healthcare System between 2002 and 2006, classified by CKD (estimated glomerular filtration rate <60?mL/min) or normal renal function. We used landmark analyses from 12 months after PCI with Cox proportional hazards multivariable and propensity-adjusted models to assess the effect of prolonged clopidogrel (more than 12? months) versus 12 months or less after PCI on clinical outcomes from 1 year to 4?years after PCI. RESULTS: Of 23?042 eligible subjects receiving PCI, 4880 (21%) had CKD. Compared with normal renal function, patients with CKD had higher risks of death or MI 1-4?years after DES (21% vs 12%, HR=1.75; 95% CI 1.51 to 2.04) or BMS (28% vs 15%, HR=2.10; 95% CI 1.90 to 2.32). In patients with CKD receiving DES, clopidogrel use of more than 12 months after PCI was associated with lower risks of death or MI (18% vs 24%, HR=0.74; 95% CI 0.58 to 0.95), and death (15% vs 23%, HR=0.61; 95% CI 0.47 to 0.80), but had no effect on repeat revascularisation 1-4?years after PCI. CONCLUSIONS: In patients with CKD, prolonging clopidogrel beyond 12?months after PCI may decrease the risk of death or MI only in patients receiving first-generation DES. These results support a patient-tailored approach to prolonging clopidogrel after PCI. |*Stents [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Clopidogrel [MESH] |Coronary Artery Disease/complications/diagnosis/mortality/*therapy [MESH] |Drug Administration Schedule [MESH] |Drug-Eluting Stents [MESH] |Female [MESH] |Glomerular Filtration Rate [MESH] |Humans [MESH] |Kidney/physiopathology [MESH] |Male [MESH] |Metals [MESH] |Middle Aged [MESH] |Multivariate Analysis [MESH] |Myocardial Infarction/etiology [MESH] |Percutaneous Coronary Intervention/adverse effects/*instrumentation/mortality [MESH] |Platelet Aggregation Inhibitors/*administration & dosage/adverse effects [MESH] |Propensity Score [MESH] |Proportional Hazards Models [MESH] |Prosthesis Design [MESH] |Renal Insufficiency, Chronic/*complications/diagnosis/mortality/physiopathology [MESH] |Risk Assessment [MESH] |Risk Factors [MESH] |Ticlopidine/administration & dosage/adverse effects/*analogs & derivatives [MESH] |Time Factors [MESH] |Treatment Outcome [MESH] |United States [MESH]Outcomes with prolonged clopidogrel therapy after coronary stenting in(epmc).pdf DeepDyve Pubget Overpricing