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10.1177/1759091415605114 http://scihub22266oqcxt.onion/10.1177/1759091415605114 C4580122!4580122 !26391329     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26391329 &cmd=llinks): Failed to open stream: HTTP request failed! 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Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice |pdf=|usr=}}{{26391329 }} gab.com Text Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice JO: ASN Neuro http://www.kidney.de/pget.php?&tw=1&pmid=26391329 #FOAvip Apelin is a peptide originally isolated from bovine stomach tissue extracts and identified as an endogenous ligand of the APJ receptor; recent work showed that apelin ameliorates the ischemic injury in the heart and the brain. Being an analogue to the angiotensin II receptor, the apelin/APJ signaling may mediate angiogenesis process. We explored the noninvasive intranasal brain delivery method and investigated therapeutic effects of apelin-13 in a focal ischemic stroke model of mice. Intranasal administration of apelin-13 (4?mg/kg) was given 30?min after the onset of stroke and repeated once daily. Three days after stroke, mice received apelin-13 had significantly reduced infarct volume and less neuronal death in the penumbra. Western blot analyses showed upregulated levels of apelin, apelin receptor APLNR, and Bcl-2 and decreased caspase-3 activation in the apelin-13-treated brain. The proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1?, and chemokine monocyte chemoattractant protein-1 mRNA increased in the ischemic brain, which were significantly attenuated by apelin-13. Apelin-13 remarkably reduced microglia recruitment and activation in the penumbra according to morphological features of Iba-1-positive cells 3 days after ischemia. Apelin-13 significantly increased the expression of angiogenic factor vascular endothelial growth factor and matrix metalloproteinase-9 14 days after stroke. Angiogenesis illustrated by collagen IV?+?/5-bromo-2'-deoxyuridin?+?colabeled cells was significantly increased by the apelin-13 treatment 21 days after stroke. Finally, apelin-13 promoted the local cerebral blood flow restoration and long-term functional recovery. This study demonstrates a noninvasive intranasal delivery of apelin-13 after stroke, suggesting that the reduced inflammatory activities, decreased cell death, and increased angiogenesis contribute to the therapeutic benefits of apelin-13. Twit Text FOAVip Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice ????ASN Neuro http://www.kidney.de/pget.php?&tw=1&pmid=26391329 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26391329 #FOAvip English Wikipedia <ref>{{Cite pmid|26391329 }}</ref> Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice #MMPMID26391329 Chen D ; Lee J ; Gu X ; Wei L ; Yu SP ASN Neuro 2015[Sep]; 7 (5 ): ä PMID26391329 show ga Apelin is a peptide originally isolated from bovine stomach tissue extracts and identified as an endogenous ligand of the APJ receptor; recent work showed that apelin ameliorates the ischemic injury in the heart and the brain. Being an analogue to the angiotensin II receptor, the apelin/APJ signaling may mediate angiogenesis process. We explored the noninvasive intranasal brain delivery method and investigated therapeutic effects of apelin-13 in a focal ischemic stroke model of mice. Intranasal administration of apelin-13 (4?mg/kg) was given 30?min after the onset of stroke and repeated once daily. Three days after stroke, mice received apelin-13 had significantly reduced infarct volume and less neuronal death in the penumbra. Western blot analyses showed upregulated levels of apelin, apelin receptor APLNR, and Bcl-2 and decreased caspase-3 activation in the apelin-13-treated brain. The proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1?, and chemokine monocyte chemoattractant protein-1 mRNA increased in the ischemic brain, which were significantly attenuated by apelin-13. Apelin-13 remarkably reduced microglia recruitment and activation in the penumbra according to morphological features of Iba-1-positive cells 3 days after ischemia. Apelin-13 significantly increased the expression of angiogenic factor vascular endothelial growth factor and matrix metalloproteinase-9 14 days after stroke. Angiogenesis illustrated by collagen IV?+?/5-bromo-2'-deoxyuridin?+?colabeled cells was significantly increased by the apelin-13 treatment 21 days after stroke. Finally, apelin-13 promoted the local cerebral blood flow restoration and long-term functional recovery. This study demonstrates a noninvasive intranasal delivery of apelin-13 after stroke, suggesting that the reduced inflammatory activities, decreased cell death, and increased angiogenesis contribute to the therapeutic benefits of apelin-13. |Administration, Intranasal [MESH] |Angiogenesis Inducing Agents/*administration & dosage [MESH] |Animals [MESH] |Brain Ischemia/*drug therapy/pathology/physiopathology [MESH] |Brain/blood supply/*drug effects/pathology/physiopathology [MESH] |Cell Death/drug effects/physiology [MESH] |Cerebrovascular Circulation/drug effects/physiology [MESH] |Disease Models, Animal [MESH] |Infarction, Middle Cerebral Artery [MESH] |Intercellular Signaling Peptides and Proteins/*administration & dosage [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Neuroimmunomodulation/drug effects/physiology [MESH] |Neurons/drug effects/pathology/physiology [MESH] |Neuroprotective Agents/*administration & dosage [MESH] |Recovery of Function/drug effects/physiology [MESH]Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angio(epmc).pdf DeepDyve Pubget Overpricing