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10.1038/cmi.2015.44 http://scihub22266oqcxt.onion/10.1038/cmi.2015.44 C4579656!4579656!26051475     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Immunol 2015 ; 12 (5): 566-71 Nephropedia Template TP {{tp|p=26051475|t=2015. Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance |pdf=|usr=}}{{26051475}} gab.com Text Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26051475 #FOAvip The lack of immune response to an antigen, a process known as immune tolerance, is essential for the preservation of immune homeostasis. To date, two mechanisms that drive immune tolerance have been described extensively: central tolerance and peripheral tolerance. Under the new nomenclature, thymus-derived regulatory T (tTreg) cells are the major mediators of central immune tolerance, whereas peripherally derived regulatory T (pTreg) cells function to regulate peripheral immune tolerance. A third type of Treg cells, termed iTreg, represents only the in vitro-induced Treg cells1. Depending on whether the cells stably express Foxp3, pTreg, and iTreg cells may be divided into two subsets: the classical CD4+Foxp3+ Treg cells and the CD4+Foxp3? type 1 regulatory T (Tr1) cells2. This review focuses on the discovery, associated biomarkers, regulatory functions, methods of induction, association with disease, and clinical trials of Tr1 cells. Twit Text FOAVip Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26051475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26051475 #FOAvip English Wikipedia <ref>{{Cite pmid|26051475}}</ref> Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance #MMPMID26051475 Zeng H; Zhang R; Jin B; Chen L Cell Mol Immunol 2015[Sep]; 12 (5): 566-71 PMID26051475show ga The lack of immune response to an antigen, a process known as immune tolerance, is essential for the preservation of immune homeostasis. To date, two mechanisms that drive immune tolerance have been described extensively: central tolerance and peripheral tolerance. Under the new nomenclature, thymus-derived regulatory T (tTreg) cells are the major mediators of central immune tolerance, whereas peripherally derived regulatory T (pTreg) cells function to regulate peripheral immune tolerance. A third type of Treg cells, termed iTreg, represents only the in vitro-induced Treg cells1. Depending on whether the cells stably express Foxp3, pTreg, and iTreg cells may be divided into two subsets: the classical CD4+Foxp3+ Treg cells and the CD4+Foxp3? type 1 regulatory T (Tr1) cells2. This review focuses on the discovery, associated biomarkers, regulatory functions, methods of induction, association with disease, and clinical trials of Tr1 cells. äType 1 regulatory T cells: a new mechanism of peripheral immune tolera(epmc).pdf DeepDyve Pubget Overpricing