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10.1038/cmi.2015.23

http://scihub22266oqcxt.onion/10.1038/cmi.2015.23
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C4579654!4579654!25891216
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suck abstract from ncbi


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pmid25891216      Cell+Mol+Immunol 2015 ; 12 (5): 543-52
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  • Tissue resident regulatory T cells: novel therapeutic targets for human disease #MMPMID25891216
  • Zhou X; Tang J; Cao H; Fan H; Li B
  • Cell Mol Immunol 2015[Sep]; 12 (5): 543-52 PMID25891216show ga
  • Over the past decade, the ability of regulatory T cells (Tregs) to suppress multiple types of immune cells has received tremendous attention. Mounting evidence has revealed that tissue resident Tregs control non-immunological processes of their target tissues and contribute to a plethora of human diseases. The identification of novel tissue-specific Tregs has highlighted their heterogeneity and complexity. This review summarizes the recent findings for visceral adipose tissue CD4+Foxp3+ regulatory T cells (VAT Tregs), muscle Tregs, bone Tregs and skin memory Tregs, with a focus on their unique functions in local tissues. This interpretation of the roles of tissue-specific Tregs and of their involvement in disease progression provides new insight into the discovery of potential therapeutic targets of human diseases.
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