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10.1038/cmi.2014.80 http://scihub22266oqcxt.onion/10.1038/cmi.2014.80 C4579649!4579649 !25176527     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25176527 &cmd=llinks): Failed to open stream: HTTP request failed! 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Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst |pdf=|usr=}}{{25176527 }} gab.com Text Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25176527 #FOAvip Influenza A virus (IAV) infection is a major worldwide public health problem. However, the factors involved in mediating the inflammatory response to this infection and their relationships remain poorly understood. Here, we show that IAV infection stimulates the expression of the soluble IL-6 receptor (sIL-6R), a multifunctional protein involved in IL-6 signaling. Interestingly, sIL-6R expression upregulated the levels of its own ligand, IL-6 and those of the pro-inflammatory cytokine IL-32. shRNA-mediated knockdown of sIL-6R suppressed IL-6 and IL-32, indicating that this regulation is dependent on sIL-6R during IAV infection. Furthermore, our results demonstrate that IL-32 participates in a negative feedback loop that inhibits sIL-6R while upregulating IL-6 expression during IAV infection. Therefore, we show that sIL-6R is a critical cellular factor involved in the acute inflammatory response to viral infection. Twit Text FOAVip Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25176527 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25176527 #FOAvip English Wikipedia <ref>{{Cite pmid|25176527 }}</ref> Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst #MMPMID25176527 Wang J ; Wang Q ; Han T ; Li YK ; Zhu SL ; Ao F ; Feng J ; Jing MZ ; Wang L ; Ye LB ; Zhu Y Cell Mol Immunol 2015[Sep]; 12 (5 ): 633-44 PMID25176527 show ga Influenza A virus (IAV) infection is a major worldwide public health problem. However, the factors involved in mediating the inflammatory response to this infection and their relationships remain poorly understood. Here, we show that IAV infection stimulates the expression of the soluble IL-6 receptor (sIL-6R), a multifunctional protein involved in IL-6 signaling. Interestingly, sIL-6R expression upregulated the levels of its own ligand, IL-6 and those of the pro-inflammatory cytokine IL-32. shRNA-mediated knockdown of sIL-6R suppressed IL-6 and IL-32, indicating that this regulation is dependent on sIL-6R during IAV infection. Furthermore, our results demonstrate that IL-32 participates in a negative feedback loop that inhibits sIL-6R while upregulating IL-6 expression during IAV infection. Therefore, we show that sIL-6R is a critical cellular factor involved in the acute inflammatory response to viral infection. |Adult [MESH] |Demography [MESH] |Feedback, Physiological [MESH] |Female [MESH] |Humans [MESH] |Inflammation/immunology/metabolism/*pathology [MESH] |Influenza A virus/immunology/*physiology [MESH] |Influenza, Human/*immunology/metabolism/*virology [MESH] |Interleukin-6/*metabolism [MESH] |Interleukins/*metabolism [MESH] |Male [MESH] |Models, Immunological [MESH] |Promoter Regions, Genetic/genetics [MESH] |Receptors, Interleukin-6/*metabolism [MESH] |Solubility [MESH]Soluble interleukin-6 receptor is elevated during influenza A virus in(epmc).pdf DeepDyve Pubget Overpricing