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10.1038/ncomms9283 http://scihub22266oqcxt.onion/10.1038/ncomms9283 C4579570!4579570 !26387534     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26387534 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2015 ; 6 (ä): 8283 Nephropedia Template TP {{tp|p=26387534 |t=2015. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling |pdf=|usr=}}{{26387534 }} gab.com Text Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26387534 #FOAvip Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and the autophagic control of intracellular nutrient levels. Here we show that class III PI3K--a master regulator of endocytosis, endosomal sorting and autophagy--provides negative feedback on hepatic insulin signalling. The ultraviolet radiation resistance-associated gene protein (UVRAG)-associated class III PI3K complex interacts with IR and is stimulated by insulin treatment. Acute and chronic depletion of hepatic Vps15, the regulatory subunit of class III PI3K, increases insulin sensitivity and Akt signalling, an effect that requires functional IR. This is reflected by FoxO1-dependent transcriptional defects and blunted gluconeogenesis in Vps15 mutant cells. On depletion of Vps15, the metabolic syndrome in genetic and diet-induced models of insulin resistance and diabetes is alleviated. Thus, feedback regulation of IR trafficking and function by class III PI3K may be a therapeutic target in metabolic conditions of insulin resistance. Twit Text FOAVip Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26387534 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26387534 #FOAvip English Wikipedia <ref>{{Cite pmid|26387534 }}</ref> Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling #MMPMID26387534 Nemazanyy I ; Montagnac G ; Russell RC ; Morzyglod L ; Burnol AF ; Guan KL ; Pende M ; Panasyuk G Nat Commun 2015[Sep]; 6 (ä): 8283 PMID26387534 show ga Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and the autophagic control of intracellular nutrient levels. Here we show that class III PI3K--a master regulator of endocytosis, endosomal sorting and autophagy--provides negative feedback on hepatic insulin signalling. The ultraviolet radiation resistance-associated gene protein (UVRAG)-associated class III PI3K complex interacts with IR and is stimulated by insulin treatment. Acute and chronic depletion of hepatic Vps15, the regulatory subunit of class III PI3K, increases insulin sensitivity and Akt signalling, an effect that requires functional IR. This is reflected by FoxO1-dependent transcriptional defects and blunted gluconeogenesis in Vps15 mutant cells. On depletion of Vps15, the metabolic syndrome in genetic and diet-induced models of insulin resistance and diabetes is alleviated. Thus, feedback regulation of IR trafficking and function by class III PI3K may be a therapeutic target in metabolic conditions of insulin resistance. |Animals [MESH] |Diabetes Mellitus/metabolism [MESH] |Feedback, Physiological [MESH] |Glucose/*metabolism [MESH] |Homeostasis [MESH] |Humans [MESH] |Insulin Resistance [MESH] |Insulin/*metabolism [MESH] |Liver/enzymology/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Phosphatidylinositol 3-Kinases/genetics/metabolism [MESH] |Receptor, Insulin/genetics/metabolism [MESH] |Signal Transduction [MESH] |Tumor Suppressor Proteins/genetics/metabolism [MESH]Class III PI3K regulates organismal glucose homeostasis by providing n(epmc).pdf DeepDyve Pubget Overpricing