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10.1038/ncomms9164 http://scihub22266oqcxt.onion/10.1038/ncomms9164 C4579523!4579523 !26353940     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26353940 &cmd=llinks): Failed to open stream: HTTP request failed! 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Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation |pdf=|usr=}}{{26353940 }} gab.com Text Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26353940 #FOAvip Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown. Here we show that fibrinogen, a central blood coagulation protein deposited in the CNS after blood-brain barrier disruption, induces encephalitogenic adaptive immune responses and peripheral macrophage recruitment into the CNS leading to demyelination. Fibrinogen stimulates a unique transcriptional signature in CD11b(+) antigen-presenting cells inducing the recruitment and local CNS activation of myelin antigen-specific Th1 cells. Fibrinogen depletion reduces Th1 cells in the multiple sclerosis model, experimental autoimmune encephalomyelitis. Major histocompatibility complex (MHC) II-dependent antigen presentation, CXCL10- and CCL2-mediated recruitment of T cells and macrophages, respectively, are required for fibrinogen-induced encephalomyelitis. Inhibition of the fibrinogen receptor CD11b/CD18 protects from all immune and neuropathologic effects. Our results show that the final product of the coagulation cascade is a key determinant of CNS autoimmunity. Twit Text FOAVip Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26353940 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26353940 #FOAvip English Wikipedia <ref>{{Cite pmid|26353940 }}</ref> Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation #MMPMID26353940 Ryu JK ; Petersen MA ; Murray SG ; Baeten KM ; Meyer-Franke A ; Chan JP ; Vagena E ; Bedard C ; Machado MR ; Rios Coronado PE ; Prod'homme T ; Charo IF ; Lassmann H ; Degen JL ; Zamvil SS ; Akassoglou K Nat Commun 2015[Sep]; 6 (ä): 8164 PMID26353940 show ga Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown. Here we show that fibrinogen, a central blood coagulation protein deposited in the CNS after blood-brain barrier disruption, induces encephalitogenic adaptive immune responses and peripheral macrophage recruitment into the CNS leading to demyelination. Fibrinogen stimulates a unique transcriptional signature in CD11b(+) antigen-presenting cells inducing the recruitment and local CNS activation of myelin antigen-specific Th1 cells. Fibrinogen depletion reduces Th1 cells in the multiple sclerosis model, experimental autoimmune encephalomyelitis. Major histocompatibility complex (MHC) II-dependent antigen presentation, CXCL10- and CCL2-mediated recruitment of T cells and macrophages, respectively, are required for fibrinogen-induced encephalomyelitis. Inhibition of the fibrinogen receptor CD11b/CD18 protects from all immune and neuropathologic effects. Our results show that the final product of the coagulation cascade is a key determinant of CNS autoimmunity. |Adaptive Immunity/drug effects/genetics/immunology [MESH] |Animals [MESH] |Antigen Presentation/drug effects/genetics/immunology [MESH] |Autoimmunity/drug effects/genetics/*immunology [MESH] |Blood-Brain Barrier [MESH] |Brain/drug effects/*immunology/metabolism/pathology [MESH] |CD11b Antigen/genetics/immunology [MESH] |CX3C Chemokine Receptor 1 [MESH] |Cell Proliferation [MESH] |Chemokine CCL2/immunology [MESH] |Chemokine CXCL10/genetics/immunology [MESH] |Chemokines [MESH] |DNA-Binding Proteins/genetics/immunology [MESH] |Demyelinating Diseases/genetics/*immunology [MESH] |Encephalomyelitis, Autoimmune, Experimental/*immunology [MESH] |Fibrin [MESH] |Fibrinogen/*immunology/pharmacology [MESH] |Flow Cytometry [MESH] |Gene Expression Profiling [MESH] |Genes, MHC Class II/genetics/*immunology [MESH] |Homeodomain Proteins/genetics/immunology [MESH] |Immunohistochemistry [MESH] |Macrophages/*immunology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Microglia [MESH] |Myelin-Oligodendrocyte Glycoprotein/immunology [MESH] |Rats [MESH] |Receptors, Antigen, T-Cell/immunology [MESH] |Receptors, Chemokine/genetics/immunology [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Spinal Cord/drug effects/*immunology/metabolism/pathology [MESH]Blood coagulation protein fibrinogen promotes autoimmunity and demyeli(epmc).pdf DeepDyve Pubget Overpricing