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2015 ; 25
(10
): 1514-20
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The intersection of microbiome and host at the skin interface: genomic- and
metagenomic-based insights
#MMPMID26430162
Grice EA
Genome Res
2015[Oct]; 25
(10
): 1514-20
PMID26430162
show ga
The past two decades have been marked by a surge in research to understand the
microbial communities that live in association with the human body, in part
stimulated by affordable, high-throughput DNA sequencing technology. In the
context of the skin, this Perspective focuses on the current state of genomic-
and metagenomic-based host-microbe research and future challenges and
opportunities to move the field forward. These include elucidating nonbacterial
components of the skin microbiome (i.e., viruses); systematic studies to address
common perturbations to the skin microbiome (e.g., antimicrobial drugs, topical
cosmetic/hygienic products); improved approaches for identifying potential
microbial triggers for skin diseases, including species- and strain-level
resolution; and improved, clinically relevant models for studying the functional
and mechanistic roles of the skin microbiome. In the next 20 years, we can
realistically expect that our knowledge of the skin microbiome will inform the
clinical management and treatment of skin disorders through diagnostic tests to
stratify patient subsets and predict best treatment modality and outcomes and
through treatment strategies such as targeted manipulation or reconstitution of
microbial communities.