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2015 ; 9
(ä): 300-9
Nephropedia Template TP
gab.com Text
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English Wikipedia
Effects of rhythmic stimulus presentation on oscillatory brain activity: the
physiology of cueing in Parkinson s disease
#MMPMID26509117
te Woerd ES
; Oostenveld R
; Bloem BR
; de Lange FP
; Praamstra P
Neuroimage Clin
2015[]; 9
(ä): 300-9
PMID26509117
show ga
The basal ganglia play an important role in beat perception and patients with
Parkinson's disease (PD) are impaired in perception of beat-based rhythms.
Rhythmic cues are nonetheless beneficial in gait rehabilitation, raising the
question how rhythm improves movement in PD. We addressed this question with
magnetoencephalography recordings during a choice response task with rhythmic and
non-rhythmic modes of stimulus presentation. Analyses focused on (i) entrainment
of slow oscillations, (ii) the depth of beta power modulation, and (iii) whether
a gain in modulation depth of beta power, due to rhythmicity, is of predictive or
reactive nature. The results show weaker phase synchronisation of slow
oscillations and a relative shift from predictive to reactive movement-related
beta suppression in PD. Nonetheless, rhythmic stimulus presentation increased
beta modulation depth to the same extent in patients and controls. Critically,
this gain selectively increased the predictive and not reactive movement-related
beta power suppression. Operation of a predictive mechanism, induced by rhythmic
stimulation, was corroborated by a sensory gating effect in the sensorimotor
cortex. The predictive mode of cue utilisation points to facilitation of basal
ganglia-premotor interactions, contrasting with the popular view that rhythmic
stimulation confers a special advantage in PD, based on recruitment of
alternative pathways.