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2015 ; 49
(5
): 396-402
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Comparison of Cytologic Characteristics between Adenoid Cystic Carcinoma and
Adenoid Basal Carcinoma in the Uterine Cervix
#MMPMID26278519
Jeong J
; Ha SY
; Cho HY
; Chung DH
; An J
J Pathol Transl Med
2015[Sep]; 49
(5
): 396-402
PMID26278519
show ga
BACKGROUND: Adenoid cystic carcinoma (ACC) and adenoid basal carcinoma (ABC) are
rare in the uterine cervix. ACC is more aggressive than ABC, thus accurate
differential diagnosis is important. In this study, we identified cytologic
features useful in distinguishing these two tumors for diagnosis. METHODS: Three
cases of ACC and five cases of ABC were selected for this study. Cervicovaginal
smear slides were reviewed retrospectively, and the area, circumference, major
axis, and minor axis of nuclei were measured using an image analyzer. RESULTS:
ACC displayed three-dimensional clusters with a small acini pattern. ABC
displayed peripheral palisading without an acini pattern. The nuclei of ACC were
more irregular and angulated than those of ABC, and the former showed a coarsely
granular chromatin pattern. The nucleic area, circumference, major axis, and
minor axis were 18.556±8.665 µm(2), 23.320±11.412 µm, 5.664±1.537 µm, and
4.127±1.107 µm in ACC and 11.017±4.440 µm(2), 15.920±5.664 µm, 4.612±1.025 µm,
and 3.088±0.762 µm in the cases of ABC. All measured values showed statistically
significant difference (p < .001). CONCLUSIONS: Although the nuclei of both of
these tumor types were oval shaped, inferred from the ratio of minor axis to
major axis (0.728 in ACC and 0.669 in ABC), the area of nuclei was approximately
1.7 times larger in ACC than in ABC. Distinguishing nucleic features, including
area, morphology, and chromatin pattern, may be helpful in making a correct
diagnosis.