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10.1371/journal.pone.0138846 http://scihub22266oqcxt.onion/10.1371/journal.pone.0138846 C4578951!4578951 !26393514     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26393514 &cmd=llinks): Failed to open stream: HTTP request failed! 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Adoptive Transfer of Treg Cells Combined with Mesenchymal Stem Cells Facilitates Repopulation of Endogenous Treg Cells in a Murine Acute GVHD Model |pdf=|usr=}}{{26393514 }} gab.com Text Adoptive Transfer of Treg Cells Combined with Mesenchymal Stem Cells Facilitates Repopulation of Endogenous Treg Cells in a Murine Acute GVHD Model JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26393514 #FOAvip Therapeutic effects of combined cell therapy with mesenchymal stem cells (MSCs) and regulatory T cells (Treg cells) have recently been studied in acute graft-versus-host-disease (aGVHD) models. However, the underlying, seemingly synergistic mechanism behind combined cell therapy has not been determined. We investigated the origin of Foxp3+ Treg cells and interleukin 17 (IL-17+) cells in recipients following allogeneic bone marrow transplantation (allo-BMT) to identify the immunological effects of combined cell therapy. Treg cells were generated from eGFP-expressing C57BL/6 mice (Tregegfp cells) to distinguish the transferred Treg cells; recipients were then examined at different time points after BMT. Systemic infusion of MSCs and Treg cells improved survival and GVHD scores, effectively downregulating pro-inflammatory Th×and Th17 cells. These therapeutic effects of combined cell therapy resulted in an increased Foxp3+ Treg cell population. Compared to single cell therapy, adoptively transferred Tregegfp cells only showed prolonged survival in the combined cell therapy group on day 21 after allogeneic BMT. In addition, Foxp3+ Treg cells, generated endogenously from recipients, significantly increased. Significantly higher levels of Tregegfp cells were also detected in aGVHD target organs in the combined cell therapy group compared to the Treg cells group. Thus, our data indicate that MSCs may induce the long-term survival of transferred Treg cells, particularly in aGVHD target organs, and may increase the repopulation of endogenous Treg cells in recipients after BMT. Together, these results support the potential of combined cell therapy using MSCs and Treg cells for preventing aGVHD. Twit Text FOAVip Adoptive Transfer of Treg Cells Combined with Mesenchymal Stem Cells Facilitates Repopulation of Endogenous Treg Cells in a Murine Acute GVHD Model ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26393514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26393514 #FOAvip English Wikipedia <ref>{{Cite pmid|26393514 }}</ref> Adoptive Transfer of Treg Cells Combined with Mesenchymal Stem Cells Facilitates Repopulation of Endogenous Treg Cells in a Murine Acute GVHD Model #MMPMID26393514 Lee ES ; Lim JY ; Im KI ; Kim N ; Nam YS ; Jeon YW ; Cho SG PLoS One 2015[]; 10 (9 ): e0138846 PMID26393514 show ga Therapeutic effects of combined cell therapy with mesenchymal stem cells (MSCs) and regulatory T cells (Treg cells) have recently been studied in acute graft-versus-host-disease (aGVHD) models. However, the underlying, seemingly synergistic mechanism behind combined cell therapy has not been determined. We investigated the origin of Foxp3+ Treg cells and interleukin 17 (IL-17+) cells in recipients following allogeneic bone marrow transplantation (allo-BMT) to identify the immunological effects of combined cell therapy. Treg cells were generated from eGFP-expressing C57BL/6 mice (Tregegfp cells) to distinguish the transferred Treg cells; recipients were then examined at different time points after BMT. Systemic infusion of MSCs and Treg cells improved survival and GVHD scores, effectively downregulating pro-inflammatory Th×and Th17 cells. These therapeutic effects of combined cell therapy resulted in an increased Foxp3+ Treg cell population. Compared to single cell therapy, adoptively transferred Tregegfp cells only showed prolonged survival in the combined cell therapy group on day 21 after allogeneic BMT. In addition, Foxp3+ Treg cells, generated endogenously from recipients, significantly increased. Significantly higher levels of Tregegfp cells were also detected in aGVHD target organs in the combined cell therapy group compared to the Treg cells group. Thus, our data indicate that MSCs may induce the long-term survival of transferred Treg cells, particularly in aGVHD target organs, and may increase the repopulation of endogenous Treg cells in recipients after BMT. Together, these results support the potential of combined cell therapy using MSCs and Treg cells for preventing aGVHD. |Acute Disease [MESH] |Adoptive Transfer [MESH] |Animals [MESH] |Bone Marrow Transplantation/*methods [MESH] |Cells, Cultured [MESH] |Combined Modality Therapy [MESH] |Disease Models, Animal [MESH] |Forkhead Transcription Factors/genetics/metabolism [MESH] |Gene Expression [MESH] |Graft Survival [MESH] |Graft vs Host Disease/genetics/metabolism/*prevention & control [MESH] |Green Fluorescent Proteins/genetics/metabolism [MESH] |Mesenchymal Stem Cell Transplantation/*methods [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Microscopy, Confocal [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |T-Lymphocytes, Regulatory/metabolism/*transplantation [MESH] |Transplantation, Homologous [MESH]Adoptive Transfer of Treg Cells Combined with Mesenchymal Stem Cells F(epmc).pdf DeepDyve Pubget Overpricing