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10.1371/journal.pone.0138200 http://scihub22266oqcxt.onion/10.1371/journal.pone.0138200 C4578940!4578940 !26394034     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26394034 &cmd=llinks): Failed to open stream: HTTP request failed! 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Immunophenotypic Profiling of Erythroid Progenitor-Derived Extracellular Vesicles in Diamond-Blackfan Anaemia: A New Diagnostic Strategy |pdf=|usr=}}{{26394034 }} gab.com Text Immunophenotypic Profiling of Erythroid Progenitor-Derived Extracellular Vesicles in Diamond-Blackfan Anaemia: A New Diagnostic Strategy JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26394034 #FOAvip Diamond-Blackfan Anaemia (DBA) is a rare inherited anaemia caused by heterozygous mutations in one of 13 ribosomal protein genes. Erythroid progenitors (BFU-E and CFU-E) in bone marrow (BM) show a proapoptotic phenotype. Suspicion of DBA is reached after exclusion of other forms of BM failure syndromes. To improve DBA diagnosis, which is confirmed by mutation analysis, we tested a new approach based on the study of extracellular vesicles (EVs) isolated from plasma by differential centrifugations and analysed by flow cytometry. We chose CD34, CD71 and CD235a markers to study erythroid EVs. We characterised the EVs immunophentoypic profiles of 13 DBA patients, 22 healthy controls and 16 patients with other haematological diseases. Among the three EVs clusters we found, only the CD34+/CD71low population showed statistically significant differences between DBA patients and controls (p< 0.05). The absence of this cluster is in agreement with the low levels of BFU-E found in DBA patients. The assessment of ROC curves demonstrated the potential diagnostic value of this population. We suggest that this assay may be useful to improve DBA diagnosis as a quicker and less invasive alternative to BM BFU-E culture analysis. Twit Text FOAVip Immunophenotypic Profiling of Erythroid Progenitor-Derived Extracellular Vesicles in Diamond-Blackfan Anaemia: A New Diagnostic Strategy ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26394034 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26394034 #FOAvip English Wikipedia <ref>{{Cite pmid|26394034 }}</ref> Immunophenotypic Profiling of Erythroid Progenitor-Derived Extracellular Vesicles in Diamond-Blackfan Anaemia: A New Diagnostic Strategy #MMPMID26394034 Macrì S ; Pavesi E ; Crescitelli R ; Aspesi A ; Vizziello C ; Botto C ; Corti P ; Quarello P ; Notari P ; Ramenghi U ; Ellis SR ; Dianzani I PLoS One 2015[]; 10 (9 ): e0138200 PMID26394034 show ga Diamond-Blackfan Anaemia (DBA) is a rare inherited anaemia caused by heterozygous mutations in one of 13 ribosomal protein genes. Erythroid progenitors (BFU-E and CFU-E) in bone marrow (BM) show a proapoptotic phenotype. Suspicion of DBA is reached after exclusion of other forms of BM failure syndromes. To improve DBA diagnosis, which is confirmed by mutation analysis, we tested a new approach based on the study of extracellular vesicles (EVs) isolated from plasma by differential centrifugations and analysed by flow cytometry. We chose CD34, CD71 and CD235a markers to study erythroid EVs. We characterised the EVs immunophentoypic profiles of 13 DBA patients, 22 healthy controls and 16 patients with other haematological diseases. Among the three EVs clusters we found, only the CD34+/CD71low population showed statistically significant differences between DBA patients and controls (p< 0.05). The absence of this cluster is in agreement with the low levels of BFU-E found in DBA patients. The assessment of ROC curves demonstrated the potential diagnostic value of this population. We suggest that this assay may be useful to improve DBA diagnosis as a quicker and less invasive alternative to BM BFU-E culture analysis. |Adolescent [MESH] |Adult [MESH] |Anemia, Diamond-Blackfan/blood/*diagnosis/genetics [MESH] |Antigens, CD/blood [MESH] |Antigens, CD34/blood [MESH] |Biomarkers/blood [MESH] |Child [MESH] |Child, Preschool [MESH] |Colony-Forming Units Assay [MESH] |Erythroid Precursor Cells/*metabolism [MESH] |Extracellular Vesicles/*metabolism [MESH] |Female [MESH] |Flow Cytometry [MESH] |Glycophorins/analysis [MESH] |Humans [MESH] |Immunophenotyping/*methods [MESH] |Infant [MESH] |Male [MESH] |Middle Aged [MESH] |ROC Curve [MESH] |Receptors, Transferrin/blood [MESH]Immunophenotypic Profiling of Erythroid Progenitor-Derived Extracellul(epmc).pdf DeepDyve Pubget Overpricing