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10.1186/s12931-015-0273-8 http://scihub22266oqcxt.onion/10.1186/s12931-015-0273-8 C4578796!4578796!26392057     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Respir+Res 2015 ; 16 (1): ä Nephropedia Template TP {{tp|p=26392057|t=2015. Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study |pdf=|usr=}}{{26392057}} gab.com Text Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study JO: Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=26392057 #FOAvip Background: Development of adult respiratory disease is influenced by events in childhood. The impact of childhood pneumonia on chronic obstructive pulmonary disease (COPD) is not well defined. We hypothesize that childhood pneumonia is a risk factor for reduced lung function and COPD in adult smokers. Methods: COPD cases and control smokers between 45?80 years old from the United States COPDGene Study were included. Childhood pneumonia was defined by self-report of pneumonia at <16 years. Subjects with lung disease other than COPD or asthma were excluded. Smokers with and without childhood pneumonia were compared on measures of respiratory disease, lung function, and quantitative analysis of chest CT scans. Results: Of 10,192 adult smokers, 854 (8.4 %) reported pneumonia in childhood. Childhood pneumonia was associated with COPD (OR 1.40; 95 % CI 1.17-1.66), chronic bronchitis, increased COPD exacerbations, and lower lung function: post-bronchodilator FEV1 (69.1 vs. 77.1 % predicted), FVC (82.7 vs. 87.4 % predicted), FEV1/FVC ratio (0.63 vs. 0.67; p?<?0.001 for all comparisons). Childhood pneumonia was associated with increased airway wall thickness on CT, without significant difference in emphysema. Having both pneumonia and asthma in childhood further increased the risk of developing COPD (OR 1.85; 95 % CI 1.10-3.18). Conclusions: Children with pneumonia are at increased risk for future smoking-related lung disease including COPD and decreased lung function. This association is supported by airway changes on chest CT scans. Childhood pneumonia may be an important factor in the early origins of COPD, and the combination of pneumonia and asthma in childhood may pose the greatest risk. Clinical trials registration: ClinicalTrials.gov, NCT00608764 (Active since January 28, 2008). Electronic supplementary material: The online version of this article (doi:10.1186/s12931-015-0273-8) contains supplementary material, which is available to authorized users. Twit Text FOAVip Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study ????Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=26392057 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26392057 #FOAvip English Wikipedia <ref>{{Cite pmid|26392057}}</ref> Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study #MMPMID26392057 Hayden LP; Hobbs BD; Cohen RT; Wise RA; Checkley W; Crapo JD; Hersh CP Respir Res 2015[]; 16 (1): ä PMID26392057show ga Background: Development of adult respiratory disease is influenced by events in childhood. The impact of childhood pneumonia on chronic obstructive pulmonary disease (COPD) is not well defined. We hypothesize that childhood pneumonia is a risk factor for reduced lung function and COPD in adult smokers. Methods: COPD cases and control smokers between 45?80 years old from the United States COPDGene Study were included. Childhood pneumonia was defined by self-report of pneumonia at <16 years. Subjects with lung disease other than COPD or asthma were excluded. Smokers with and without childhood pneumonia were compared on measures of respiratory disease, lung function, and quantitative analysis of chest CT scans. Results: Of 10,192 adult smokers, 854 (8.4 %) reported pneumonia in childhood. Childhood pneumonia was associated with COPD (OR 1.40; 95 % CI 1.17-1.66), chronic bronchitis, increased COPD exacerbations, and lower lung function: post-bronchodilator FEV1 (69.1 vs. 77.1 % predicted), FVC (82.7 vs. 87.4 % predicted), FEV1/FVC ratio (0.63 vs. 0.67; p? äChildhood pneumonia increases risk for chronic obstructive pulmonary d(epmc).pdf DeepDyve Pubget Overpricing