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10.1155/2015/798754 http://scihub22266oqcxt.onion/10.1155/2015/798754 C4578751!4578751!26436098     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26436098|t=2015. Ultrastructural Morphology of Sperm from Human Globozoospermia |pdf=|usr=}}{{26436098}} gab.com Text Ultrastructural Morphology of Sperm from Human Globozoospermia JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26436098 #FOAvip Globozoospermia is a rare disorder characterized by the presence of sperm with round head, lacking acrosome. Coiling tail around the nucleus has been reported since early human studies, but no specific significance has conferred it. By contrast, studies on animal models suggest that coiling tail around the nucleus could represent a crucial step of defective spermatogenesis, resulting in round-headed sperm. No observations, so far, support the transfer of this hypothesis to human globozoospermia. The purpose of this work was to compare ultrastructural morphology of human and mouse model globozoospermic sperm. Sperm have been investigated by using scanning and transmission electron microscopy. The images that we obtained show significant similarities to those described in GOPC knockout mice, an animal model of globozoospermia. By using this model as reference, we were able to identify the probable steps of the tail coiling process in human globozoospermia. Although we have no evidence that there is the same pathophysiology in man and knocked-out mouse, the similarities between these ultrastructural observations in human and those in the experimental model are very suggestive. This is the first demonstration of the existence of relevant morphological homologies between the tail coiling in animal model and human globozoospermia. Twit Text FOAVip Ultrastructural Morphology of Sperm from Human Globozoospermia ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26436098 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26436098 #FOAvip English Wikipedia <ref>{{Cite pmid|26436098}}</ref> Ultrastructural Morphology of Sperm from Human Globozoospermia #MMPMID26436098 Ricci G; Andolfi L; Zabucchi G; Luppi S; Boscolo R; Martinelli M; Zweyer M; Trevisan E Biomed Res Int 2015[]; 2015 (ä): ä PMID26436098show ga Globozoospermia is a rare disorder characterized by the presence of sperm with round head, lacking acrosome. Coiling tail around the nucleus has been reported since early human studies, but no specific significance has conferred it. By contrast, studies on animal models suggest that coiling tail around the nucleus could represent a crucial step of defective spermatogenesis, resulting in round-headed sperm. No observations, so far, support the transfer of this hypothesis to human globozoospermia. The purpose of this work was to compare ultrastructural morphology of human and mouse model globozoospermic sperm. Sperm have been investigated by using scanning and transmission electron microscopy. The images that we obtained show significant similarities to those described in GOPC knockout mice, an animal model of globozoospermia. By using this model as reference, we were able to identify the probable steps of the tail coiling process in human globozoospermia. Although we have no evidence that there is the same pathophysiology in man and knocked-out mouse, the similarities between these ultrastructural observations in human and those in the experimental model are very suggestive. This is the first demonstration of the existence of relevant morphological homologies between the tail coiling in animal model and human globozoospermia. äUltrastructural Morphology of Sperm from Human Globozoospermia (epmc).pdf DeepDyve Pubget Overpricing